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Literature summary for 1.14.11.18 extracted from

  • Jansen, G.A.; Mihalik, S.J.; Watkins, P.A.; Jakobs, C.; Moser, H.W.; Wanders, R.J.A.
    Characterization of phytanoyl-Coenzyme A hydroxylase in human liver and activity measurements in patients with peroxisomal disorders (1998), Clin. Chim. Acta, 271, 203-211.
    View publication on PubMed
Search for more literature for 1.14.11.18

Activating Compound

Activating Compound Comment Organism Structure
ascorbate 2.5fold induction at 5 mM Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by bifonazole, clotrimazole, miconazole, ketoconazole Homo sapiens
propyl gallate no activity with 1 mM, interacts with iron binding Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.049
-
 2-oxoglutarate
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ requirement Homo sapiens
Fe2+ optimal activity at 0.5 mM Homo sapiens
additional information Cu2+, Mn2+ or Zn2+ can not replace Fe2+ Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000041
-
 in liver homogenate Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phytanoyl-CoA + 2-oxoglutarate + O2
-
 Homo sapiens alpha-hydroxyphytanoyl-CoA + succinate + CO2
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8.5 at pH 6.5 over 80%, at pH 8.5 50% of control activity Homo sapiens