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Literature summary for 1.14.11.1 extracted from
- Clofibrate treatment up-regulates novel organic cation transporter (OCTN)-2 in tissues of pigs as a model of non-proliferating species (2008), Eur. J. Pharmacol., 583, 11-17.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | activity of gamma-butyrobetaine dioxygenase in the liver is lower in pigs treated with clofibrate than in control pigs. Concentrations of gamma-butyrobetaine does not differ between both groups. Pigs treated with clofibrate have higher relative mRNA concentrations of organic cation transporter OCTN2 in liver, skeletal muscle and epithelial cells from small intestine than control pigs. Pigs treated with clofibrate have also higher concentrations of free and total carnitine in the liver and a higher concentration of free carnitine in skeletal muscle than control pigs | Sus scrofa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Clofibrate | activity of gamma-butyrobetaine dioxygenase in the liver is lower in pigs treated with clofibrate than in control pigs | Sus scrofa |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | activity of gamma-butyrobetaine dioxygenase in the liver is lower in pigs treated with clofibrate than in control pigs. Concentrations of gamma-butyrobetaine does not differ between both groups | Sus scrofa | - |
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