Literature summary for 1.14.11.1 extracted from

van Vlies, N.; Ferdinandusse, S.; Turkenburg, M.; Wanders, R.J.; Vaz, F.M.
PPARalpha-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation (2007), Biochim. Biophys. Acta, 1767, 1134-1142.

Search for more literature for 1.14.11.1

Application

Application	Comment	Organism
medicine	both enhancement of carnitine biosynthesis due to increased ?-butyrobetaine dioxygenase activity, extra-hepatic gamma-butyrobetaine synthesis and increased hepatic carnitine import contributes to the increased hepatic carnitine levels after fasting	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	both enhancement of carnitine biosynthesis due to increased gamma-butyrobetaine dioxygenase activity, extra-hepatic gamma-butyrobetaine synthesis and increased hepatic carnitine import contributes to the increased hepatic carnitine levels after fasting	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	untreated, fasted or Wy-14643-treated wild type and peroxisome proliferator activated receptor alpha-/- mice	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	both enhancement of carnitine biosynthesis due to increased gamma-butyrobetaine dioxygenase activity, extra-hepatic gamma-butyrobetaine synthesis and increased hepatic carnitine import contributes to the increased hepatic carnitine levels after fasting	Mus musculus	?	-	?

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Release 2023.1 (January 2023)