Literature summary for 1.13.12.5 extracted from

Liu, X.; Kramer, J.A.; Hu, Y.; Schmidt, J.M.; Jiang, J.; Wilson, A.G.E.
Development of a high-throughput human hepG2 dual luciferase assay for detection of metabolically activated hepatotoxicants and genotoxicants (2009), Int. J. Toxicol., 28, 162-179.

Application

Application	Comment	Organism
pharmacology	used as an assay for assessing potential liver toxicity by measuring GADD45-beta induction as an control for increased DNA damage	Renilla sp.

Cloned (Comment)	Organism
expression in Hep-G2 cell	Renilla sp.

Inhibitors	Comment	Organism
2-acetylaminofluorene	-	Renilla sp.
2-aminoanthracene	-	Renilla sp.
2-nitrofluorene	-	Renilla sp.
4-acetylaminofluorene	-	Renilla sp.
4-nitroquinoline-N-oxide	-	Renilla sp.
acetaminophen	-	Renilla sp.
actinomycin D	-	Renilla sp.
albendazole	-	Renilla sp.
amiodarone	-	Renilla sp.
ara C	-	Renilla sp.
arsenic III oxide	-	Renilla sp.
bleomycin	-	Renilla sp.
carbamzepine	-	Renilla sp.
chlorambucil	-	Renilla sp.
chlorpromazine	-	Renilla sp.
cisplatin	-	Renilla sp.
cyclophosphamide	-	Renilla sp.
cyclosporin A	-	Renilla sp.
cytochalasin B	-	Renilla sp.
digoxin	-	Renilla sp.
dimethylnitrosamine	-	Renilla sp.
ethyl methanesulfonate	-	Renilla sp.
etoposide	-	Renilla sp.
gemfibrozil	-	Renilla sp.
haloperidol	-	Renilla sp.
methylmethane sulfonate	-	Renilla sp.
mitomycin	-	Renilla sp.
N-methyl-N'-nitro-nitroso-guanidin	-	Renilla sp.
nefazodone	-	Renilla sp.
phenytoin	-	Renilla sp.
Sodium azide	-	Renilla sp.
tacrine	-	Renilla sp.
taxol	-	Renilla sp.
troglitazone	-	Renilla sp.
Valproic acid	-	Renilla sp.
vinblastin	-	Renilla sp.

Organism	UniProt	Comment	Textmining
Renilla sp.	-	-	-

Synonyms	Comment	Organism
firefly luciferase	-	Renilla sp.
Renilla luciferase	-	Renilla sp.