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Literature summary for 1.13.11.75 extracted from

  • Scherzinger, D.; Scheffer, E.; Bar, C.; Ernst, H.; Al-Babili, S.
    The Mycobacterium tuberculosis ORF Rv0654 encodes a carotenoid oxygenase mediating central and excentric cleavage of conventional and aromatic carotenoids (2010), FEBS J., 277, 4662-4673.
    View publication on PubMed
Search for more literature for 1.13.11.75

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00415
-
 beta-apo-8'-carotenal pH 7.9, 28°C Mycobacterium tuberculosis
0.0219
-
 3-hydroxy-beta-apo-8'-carotenal pH 7.9, 28°C Mycobacterium tuberculosis
0.0294
-
 beta-apo-10'-carotenal pH 7.9, 28°C Mycobacterium tuberculosis
0.0438
-
 3-hydroxy-beta-apo-10'-carotenal pH 7.9, 28°C Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WPR5
-
-
Mycobacterium tuberculosis H37Rv P9WPR5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3'-dihydoxyisorenieratene + O2 54% cleavage at C15-C15' double bond, 45% cleavage at the C13-C14 double bond Mycobacterium tuberculosis ?
-
 ?
3,3'-dihydoxyisorenieratene + O2 54% cleavage at C15-C15' double bond, 45% cleavage at the C13-C14 double bond Mycobacterium tuberculosis H37Rv ?
-
 ?
3-hydroxy-beta-apo-10'-carotenal + O2 3% cleavage at C15-C15' double bond, 97% cleavage at the C13-C14 double bond Mycobacterium tuberculosis ?
-
 ?
3-hydroxy-beta-apo-8'-carotenal + O2 95% cleavage at C15-C15' double bond, 5% cleavage at the C13-C14 double bond Mycobacterium tuberculosis ?
-
 ?
beta-apo-10'-carotenal + O2 79% cleavage at C13-C14 double bond, 20% cleavage at the C15-C15' double bond Mycobacterium tuberculosis ?
-
 ?
beta-apo-10'-carotenal + O2 79% cleavage at C13-C14 double bond, 20% cleavage at the C15-C15' double bond Mycobacterium tuberculosis H37Rv ?
-
 ?
beta-apo-8'-carotenal + O2 86% cleavage at C13-C14 double bond, 14% cleavage at the C15-C15' double bond Mycobacterium tuberculosis ?
-
 ?
beta-apo-8'-carotenal + O2 86% cleavage at C13-C14 double bond, 14% cleavage at the C15-C15' double bond Mycobacterium tuberculosis H37Rv ?
-
 ?
beta-carotene + O2 30% cleavage at C13-C14 double bond, 69% cleavage at the C15-C15' double bond Mycobacterium tuberculosis retinal + beta-apo-14'-carotenal + beta-apo-13-carotenone
-
 ?
lutein + O2 54% cleavage at C15-C15' double bond, 45% cleavage at the C13-C14 double bond Mycobacterium tuberculosis ?
-
 ?
additional information MtCCO cleaves the central C15-C15' and an excentric double bond at the C13-C14 position. The preference for each of the cleavage positions is determined by the hydroxylation and the nature of the ionone ring Mycobacterium tuberculosis ?
-
 ?
additional information MtCCO cleaves the central C15-C15' and an excentric double bond at the C13-C14 position. The preference for each of the cleavage positions is determined by the hydroxylation and the nature of the ionone ring Mycobacterium tuberculosis H37Rv ?
-
 ?
zeaxanthin + O2 83% cleavage at C15-C15' double bond, 17% cleavage at the C13-C14 double bond Mycobacterium tuberculosis ?
-
 ?
zeaxanthin + O2 83% cleavage at C15-C15' double bond, 17% cleavage at the C13-C14 double bond Mycobacterium tuberculosis H37Rv ?
-
 ?

Synonyms

Synonyms Comment Organism
carotenoid cleavage oxygenase
-
 Mycobacterium tuberculosis
CCO
-
 Mycobacterium tuberculosis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
392
-
 beta-apo-8'-carotenal pH 7.9, 28°C Mycobacterium tuberculosis
561
-
 beta-apo-10'-carotenal pH 7.9, 28°C Mycobacterium tuberculosis
764
-
 3-hydroxy-beta-apo-10'-carotenal pH 7.9, 28°C Mycobacterium tuberculosis
1307
-
 3-hydroxy-beta-apo-8'-carotenal pH 7.9, 28°C Mycobacterium tuberculosis