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Literature summary for 1.13.11.63 extracted from

  • Amengual, J.; Widjaja-Adhi, M.A.; Rodriguez-Santiago, S.; Hessel, S.; Golczak, M.; Palczewski, K.; von Lintig, J.
    Two carotenoid-oxygenases contribute to mammalian pro-vitamin A metabolism (2013), J. Biol. Chem., 288, 34081-34096.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.63

Application

Application Comment Organism
synthesis stepwise cleavage by BCO2, i.e. beta-carotene-9',10'-oxygenase, and BCO1 with beta-apo-10'-carotenol as an intermediate can provide a mechanism to tailor asymmetric carotenoids such as beta-cryptoxanthin for vitamin A production Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information subjection of wild type, Bco1-/-, Bco2-/-, and Bco1-/-/Bco2-/- double knock-out mice to a controlled diet providing beta-carotene as the sole source for apocarotenoid production Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-apo-10'-carotenol + O2 Mus musculus beta-apo-10'-carotenol is the major long-chain beta-apocarotenoid in mouse liver ?
-
 ?
beta-carotene + O2 Mus musculus
-
 2 all-trans-retinal
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JJS6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-apo-10'-carotenol + O2 beta-apo-10'-carotenol is the major long-chain beta-apocarotenoid in mouse liver Mus musculus ?
-
 ?
beta-carotene + O2
-
 Mus musculus 2 all-trans-retinal
-
 ?
additional information symmetric cleavage by BCO1 yields retinoids, i.e. beta-15'-apocarotenoids, C20 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
BCO1
-
 Mus musculus
beta-carotene-15,15'-oxygenase
-
 Mus musculus