Literature summary for 1.13.11.63 extracted from

Nagao, A.; Maeda, M.; Lim, B.P.; Kobayashi, H.; Terao, J.
Inhibition of beta-carotene-15,15'-dioxygenase activity by dietary flavonoids (2000), J. Nutr. Biochem., 11, 348-355.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1,1'-biphenyl	-	Sus scrofa
1,10-phenanthroline	-	Sus scrofa
2,6-di-tert-butyl-4-methylphenol	0.001 mM, strong mixed-type inhibition	Sus scrofa
3,5-di-tert-butyltoluene	-	Sus scrofa
butylated hydroxyanisole	moderate inhibition	Sus scrofa
curcumin	moderate inhibition	Sus scrofa
luteolin	remarkable noncompetitive inhibition	Sus scrofa
additional information	catechol structure of the ring B and a planar flavone structure are essential for inhibition	Sus scrofa
n-propyl gallate	moderate inhibition	Sus scrofa
nordihydroguaiaretic acid	moderate inhibition	Sus scrofa
phenanthrene	-	Sus scrofa
phloretin	remarkable noncompetitive inhibition	Sus scrofa
quercetin	remarkable noncompetitive inhibition	Sus scrofa
Rhamnetin	remarkable noncompetitive inhibition	Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
beta-carotene + O2	Sus scrofa	the enzyme is responsible for providing vertebrates with vitamin A by catalyzing oxidative cleavage of beta-carotene at its central double bond to two molecules of retinal in intestinal cells	retinal	-	?

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
intestine	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
beta-carotene + O2	the enzyme is responsible for providing vertebrates with vitamin A by catalyzing oxidative cleavage of beta-carotene at its central double bond to two molecules of retinal in intestinal cells	Sus scrofa	retinal	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00079	-	2,6-di-tert-butyl-4-methylphenol	-	Sus scrofa
0.0058	-	Rhamnetin	-	Sus scrofa
0.0099	-	phloretin	-	Sus scrofa
0.0133	-	luteolin	-	Sus scrofa
0.0169	-	curcumin	-	Sus scrofa
0.0474	-	butylated hydroxyanisole	-	Sus scrofa
0.1187	-	3,5-di-tert-butyltoluene	-	Sus scrofa

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Release 2023.1 (January 2023)