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Literature summary for 1.13.11.60 extracted from
- BW A4C and other hydroxamic acids are potent inhibitors of linoleic acid 8R-dioxygenase of the fungus Gaeumannomyces graminis (1994), Eur. J. Pharmacol., 254, 43-47.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | 2.5 mM, 50% inhibition | Gaeumannomyces graminis |  |
| 2-mercaptoethanol | - |
Gaeumannomyces graminis | |
| diclofenac | 0.2 mM, over 80% inhibition | Gaeumannomyces graminis | |
| dithiothreitol | - |
Gaeumannomyces graminis | |
| eicosatetraynoic acid | - |
Gaeumannomyces graminis | |
| linoleate-hydroxamic acid | - |
Gaeumannomyces graminis | |
| additional information | GSH (1 mM), GSSG (1 mM), EDTA (1 or 10 mM), EGTA (1 or 10 mM) and H202 (10 mM) are without effect on the 8R-dioxygenase | Gaeumannomyces graminis | |
| N-[(E)-3-(3-phenoxyphenyl)prop-2-enyl]acetohydroxamic acid | i.e. BW A4C | Gaeumannomyces graminis | |
| nordihydroguaiaretic acid | - |
Gaeumannomyces graminis | |
| paracetamol | 0.2 mM, over 80% inhibition | Gaeumannomyces graminis | |
| phenylmethanesulfonyl fluoride | 0.2 mM, inhibits the 8R-dioxygenase enzyme by over 85% | Gaeumannomyces graminis | |
| zileuton | - |
Gaeumannomyces graminis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| linoleate + O2 | Gaeumannomyces graminis | - |
(8R,10E,12Z)-8-hydroperoxy-10,12-octadecadienoate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gaeumannomyces graminis | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mycelium | - |
Gaeumannomyces graminis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| linoleate + O2 | - |
Gaeumannomyces graminis | (8R,10E,12Z)-8-hydroperoxy-10,12-octadecadienoate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | 7.6 | - |
Gaeumannomyces graminis |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 9 | stable | Gaeumannomyces graminis |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.002 | - |
pH and temperature not specified in the publication | Gaeumannomyces graminis | N-[(E)-3-(3-phenoxyphenyl)prop-2-enyl]acetohydroxamic acid | |
| 0.003 | 0.01 | pH and temperature not specified in the publication | Gaeumannomyces graminis | zileuton | |
| 0.02 | - |
pH and temperature not specified in the publication | Gaeumannomyces graminis | linoleate-hydroxamic acid | |
| 0.09 | - |
pH and temperature not specified in the publication | Gaeumannomyces graminis | nordihydroguaiaretic acid | |
| 0.1 | - |
pH and temperature not specified in the publication | Gaeumannomyces graminis | dithiothreitol | |
| 0.15 | - |
pH and temperature not specified in the publication | Gaeumannomyces graminis | eicosatetraynoic acid | |
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