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Literature summary for 1.13.11.6 extracted from
- Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro (1986), J. Neurochem., 47, 23-30.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not at a concentration of 0.5 mM: L-tryptophan, quinolinic acid, kynurenic acid, nicotinic acid mononucleotide, picolinic acid, phthalic acid, glutaric acid, L-aspartic acid, L-glutamic acid, N-methyl-D-aspartic acid, kainic acid | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.003 | 0.0036 | 3-hydroxyanthranilic acid | - |
Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | requirement | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxyanthranilate + O2 | Rattus norvegicus | in mammalian peripheral organs the enzyme constitutes a link in the catabolic pathway of tryptophan to NAD+ | 2-amino-3-carboxymuconate semialdehyde | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | regional distribution | Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -80°C, as homogenate stable for 2 months | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxyanthranilate + O2 | high selectivity for substrate | Rattus norvegicus | 2-amino-3-carboxymuconate semialdehyde | reacts spontaneously to quinolinic acid | ? | |
| 3-hydroxyanthranilate + O2 | in mammalian peripheral organs the enzyme constitutes a link in the catabolic pathway of tryptophan to NAD+ | Rattus norvegicus | 2-amino-3-carboxymuconate semialdehyde | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 7 | at pH 4.5: about 70% of activity maximum, at pH 7.0: about 50% of activity maximum | Rattus norvegicus |
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Release 2023.1 (January 2023)
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