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Literature summary for 1.13.11.58 extracted from

  • Hamberg, M.; Olsson, U.
    Efficient and specific conversion of 9-lipoxygenase hydroperoxides in the beetroot. Formation of pinellic acid (2011), Lipids, 46, 873-878.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
linoleate + O2 Beta vulgaris regiospecificity of Nb-9-LOX, overview (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
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Organism

Organism UniProt Comment Textmining
Beta vulgaris
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ssp. vulgaris
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Source Tissue

Source Tissue Comment Organism Textmining
root
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Beta vulgaris
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
linoleate + O2 regiospecificity of Nb-9-LOX, overview Beta vulgaris (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
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?

Synonyms

Synonyms Comment Organism
9-lipoxygenase
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Beta vulgaris
linoleate 9-lipoxygenase
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Beta vulgaris

General Information

General Information Comment Organism
metabolism 9-lipoxygenase-generated fatty acid hydroperoxides are converted into specific trihydroxy acids by the EAS-epoxide hydrolase pathway in the beetroot. The linolenic acid-derived hydroperoxide 9(S)-hydroperoxy-10(E),12(Z),15(Z)-octadecatrienoic acid is converted into 9(S),12(S),13(S)-trihydroxy-10(E),15(Z)-octadecadienoic acid (fulgidic acid). On the other hand, the 13-lipoxygenase-generated hydroperoxides of linoleic or linolenic acids fail to produce significant amounts of trihydroxy acids. Short-time incubation of 9(S)-hydroperoxy-10(E),12(Z)-octadecadienoic acid affords the epoxy alcohol 12(R),13(S)-epoxy-9(S)-hydroxy-10(E)-octadecenoic acid as the main product indicating the sequence 9-hydroperoxide to epoxy alcohol to trihydroxy acid catalyzed by epoxy alcohol synthase and epoxide hydrolase activities, respectively Beta vulgaris