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Literature summary for 1.13.11.53 extracted from
- One protein, two enzymes revisited: A structural entropy switch interconverts the two isoforms of acireductone dioxygenase (2006), J. Mol. Biol., 363, 823-834.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli strain BL21(DE3)pLysS | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| H98S | mutation results in the formation of a stable soluble protein that while structurally different from ARD-Ni+2 shows a high degree of similarity to the ARD'(Fe) enzyme | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ni2+ | Ni2+ can be conservatively replaced by Mn2 +or Co2+, giving rise to ARD activity (CO production) | Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 | - |
Mus musculus | 4-methylthio-2-ketobutyrate + formate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | x-ray crystallography | Mus musculus |
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Release 2023.1 (January 2023)
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