Literature summary for 1.13.11.52 extracted from

Mao, R.; Zhang, J.; Jiang, D.; Cai, D.; Levy, J.M.; Cuconati, A.; Block, T.M.; Guo, J.T.; Guo, H.
Indoleamine 2,3-dioxygenase mediates the antiviral effect of gamma interferon against hepatitis B virus in human hepatocyte-derived cells (2011), J. Virol., 85, 1048-1057.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-methyl-L-tryptophan	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tryptophan + O2	Homo sapiens	-	N-formyl-L-kynurenine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14902	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + O2	-	Homo sapiens	N-formyl-L-kynurenine	-	?

Synonyms

Synonyms	Comment	Organism
IDO	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
heme	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	IDO expression is not induced by interferon-alpha	additional information
Homo sapiens	IDO is an interferon-gamma-induced enzyme	up

General Information

General Information	Comment	Organism
physiological function	indoleamine 2,3-dioxygenase mediates the antiviral effect of interferon-gamma against hepatitis B virus in human hepatocyte-derived cells, indoleamine 2,3-dioxygenase efficiently reduces the level of intracellular hepatitis B virus DNA without altering the steady-state level of viral RNA	Homo sapiens

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Release 2023.1 (January 2023)