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Literature summary for 1.13.11.52 extracted from

  • Tattevin, P.; Monnier, D.; Tribut, O.; Dulong, J.; Bescher, N.; Mourcin, F.; Uhel, F.; Le Tulzo, Y.; Tarte, K.
    Enhanced indoleamine 2,3-dioxygenase activity in patients with severe sepsis and septic shock (2010), J. Infect. Dis., 201, 956-966.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Homo sapiens
-
N-formyl-L-kynurenine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-
lymphocyte
-
Homo sapiens
-
mesenchymal stem cell
-
Homo sapiens
-
monocyte monocytes are a major source of active IDO in normal peripheral blood Homo sapiens
-
peripheral blood mononuclear cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
Homo sapiens N-formyl-L-kynurenine
-
?

Synonyms

Synonyms Comment Organism
IDO
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens IDO activity is increased during severe sepsis and septic shock and is associated with mortality. IDO activity is maximal in culture after 3 days of interferon-gamma stimulation up