Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-methyl-D-tryptophan | competitive inhibitor | Homo sapiens | |
1-methyl-L-tryptophan | competitive inhibitor | Homo sapiens | |
4-amino-1,2,3-oxadiazole-3-carboximidamide | - |
Homo sapiens | |
annulin B | - |
Homo sapiens | |
beta-carboline | - |
Homo sapiens | |
brassinin | - |
Homo sapiens | |
epigallocatechin gallate | - |
Homo sapiens | |
exiguamine A | - |
Homo sapiens | |
exiguamine B | - |
Homo sapiens | |
menadione | - |
Homo sapiens | |
methyl-thiohydantoin-L-tryptophan | competitive inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dendritic cell | - |
Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO1 | - |
Homo sapiens |
indoleamine 2,3-dioxygenase 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.019 | - |
1-methyl-L-tryptophan | pH and temperature not specified in the publication | Homo sapiens | |
0.1 | - |
1-methyl-D-tryptophan | pH and temperature not specified in the publication | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | IDO expression is negatively regulated by interleukin-4, nitric oxide and transforming growth factor-beta | down |
Homo sapiens | IDO expression is positively regulated by interferon-gamma, CD40 ligand, COX-2, lipopolysaccharide, tumor necrosis factor-alpha, and hepatocyte growth factor | up |
General Information | Comment | Organism |
---|---|---|
physiological function | indoleamine 2,3-dioxygenase activity is implicated in the promotion of tolerance to tumors and in autoimmune and inflammatory conditions, itplays a role in arthritis, ischemia-reperfusion injury, haemostatic system, sepsis, atherosclerosis, diabetes, and gut, allergy, and airway inflammation | Homo sapiens |