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Literature summary for 1.13.11.52 extracted from

  • Thomas, S.R.; Stocker, R.
    Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway (1999), Redox Rep., 4, 199-220.
    View publication on PubMed
Search for more literature for 1.13.11.52

Activating Compound

Activating Compound Comment Organism Structure
alpha-interferon induces IDO expression in monocytes Homo sapiens
beta-interferon induces IDO expression in monocytes Homo sapiens
gamma-interferon induces IDO expression Mus musculus
gamma-interferon induces IDO expression Homo sapiens
gamma-interferon induces IDO expression Oryctolagus cuniculus
hyperoxia induces IDO expression in the lung Oryctolagus cuniculus
lipopolysaccharide induces IDO expression in monocytes Homo sapiens
lipopolysaccharide induces IDO expression in the lung Oryctolagus cuniculus
paraquat induces IDO expression in the lung Oryctolagus cuniculus

Application

Application Comment Organism
medicine plays a role in the antiparasitic defense in humans, inhibits the growth of tumor cell lines in vitro, inhibits T lymphocyte proliferation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-Methyltryptophan treatment of pregnant mice result in rapid T-cell-induces rejection of allogeneic concepti Mus musculus
dexamethasone inhibits IDO activity in brain and lung after systemic pokeweed mitogen administration and brains of mice suffering from malaria Mus musculus
dexamethasone
-
 Oryctolagus cuniculus
H2O2
-
 Homo sapiens
H2O2
-
 Mus musculus
interleukin-4
-
 Homo sapiens
NO
-
 Homo sapiens
NO inhibits the transcription of IDO in murine macrophages Mus musculus
transforming growth factor-beta inhibits expression in skin and synovial fibroblasts Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Mus musculus
-
 N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2 Oryctolagus cuniculus
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 pregnant
-
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
cerebrospinal fluid from humans suffering from inflammatory neurological disorders exhibit increased IDO activity Homo sapiens
-
epididymis
-
 Mus musculus
-
lung
-
 Mus musculus
-
lung
-
 Oryctolagus cuniculus
-
lung cancer bearing lung exhibits 20fold increase in IDO activity Homo sapiens
-
monocyte induced by alpha-, beta- and gamma-interferon Homo sapiens
-
skin fibroblast
-
 Homo sapiens
-
small intestine
-
 Mus musculus
-
synovial fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Mus musculus N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2
-
 Oryctolagus cuniculus N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
IDO
-
 Mus musculus
IDO
-
 Homo sapiens
IDO
-
 Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
additional information O2- Mus musculus
additional information O2- Homo sapiens
additional information O2- Oryctolagus cuniculus