Activating Compound | Comment | Organism | Structure |
---|---|---|---|
alpha-interferon | induces de novo synthesis of IDO, but 2 to 3 orders of magnitude less than gamma-IFN | Homo sapiens | |
gamma-interferon | induces de novo synthesis of IDO, 30fold increase in IDO activity | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
43000 | - |
gel filtration, lung | Homo sapiens |
320000 | - |
gel filtration, liver | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | Homo sapiens | - |
N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
with lung cancer | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000011 | - |
pulmonary IDO activity in pneumothorax patients | Homo sapiens |
0.000014 | - |
pulmonary IDO activity in benign tumor patient | Homo sapiens |
0.000015 | - |
pulmonary IDO activity in tuberculosis patient | Homo sapiens |
0.000039 | - |
pulmonary IDO activity in bronchiectasis patient | Homo sapiens |
0.00005 | - |
pulmonary IDO activity in lung cancer patients | Homo sapiens |
0.000067 | - |
pulmonary IDO activity in pulmonary abscess patient | Homo sapiens |
0.00033 | - |
crude extract of human lung slices treated with gamma-IFN | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | - |
Homo sapiens | N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO | - |
Homo sapiens |