Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.52 extracted from

  • Yasui, H.; Takai, K.; Yoshida, R.; Hayaishi, O.
    Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients (1986), Proc. Natl. Acad. Sci. USA, 83, 6622-6626.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
alpha-interferon induces de novo synthesis of IDO, but 2 to 3 orders of magnitude less than gamma-IFN Homo sapiens
gamma-interferon induces de novo synthesis of IDO, 30fold increase in IDO activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
gel filtration, lung Homo sapiens
320000
-
gel filtration, liver Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-tryptophan + O2 Homo sapiens
-
N-formyl-D-kynurenine
-
?
L-tryptophan + O2 Homo sapiens
-
N-formyl-L-kynurenine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
with lung cancer
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
lung
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000011
-
pulmonary IDO activity in pneumothorax patients Homo sapiens
0.000014
-
pulmonary IDO activity in benign tumor patient Homo sapiens
0.000015
-
pulmonary IDO activity in tuberculosis patient Homo sapiens
0.000039
-
pulmonary IDO activity in bronchiectasis patient Homo sapiens
0.00005
-
pulmonary IDO activity in lung cancer patients Homo sapiens
0.000067
-
pulmonary IDO activity in pulmonary abscess patient Homo sapiens
0.00033
-
crude extract of human lung slices treated with gamma-IFN Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-tryptophan + O2
-
Homo sapiens N-formyl-D-kynurenine
-
?
L-tryptophan + O2
-
Homo sapiens N-formyl-L-kynurenine
-
?

Synonyms

Synonyms Comment Organism
IDO
-
Homo sapiens