Literature summary for 1.13.11.52 extracted from

Fuchs, D.; Moller, A.A.; Reibnegger, G.; Werner, E.R.; Werner-Felmayer, G.; Dierich, M.P.; Wachter, H.
Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection (1991), Immunol. Lett., 28, 207-211.

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Activating Compound

Activating Compound	Comment	Organism	Structure
gamma-interferon	-	Human Immunodeficiency Virus

Application

Application	Comment	Organism
medicine	reduced tryptophan and increased kynurenine concentrations, chronic immune activation which can be referred to increased IDO activation	Human Immunodeficiency Virus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tryptophan + O2	Human Immunodeficiency Virus	-	N-formyl-L-kynurenine	-	?

Organism

Organism	UniProt	Comment	Textmining
Human Immunodeficiency Virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + O2	-	Human Immunodeficiency Virus	N-formyl-L-kynurenine	-	?

Synonyms

Synonyms	Comment	Organism
IDO	-	Human Immunodeficiency Virus

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Release 2023.1 (January 2023)