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Literature summary for 1.13.11.50 extracted from

  • Diebold, A.R.; Straganz, G.D.; Solomon, E.I.
    Spectroscopic and computational studies of alpha-keto acid binding to Dke1: understanding the role of the facial triad and the reactivity of beta-diketones (2011), J. Am. Chem. Soc., 133, 15979-15991.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.50

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ active site nonheme monoiron(II) center, facially ligated by three histidine residues, overview. Spectral analysis of Dke1 FeII-alpha-keto acid complexes with 4-hydroxyphneylpyruvate, overview Acinetobacter johnsonii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Acinetobacter johnsonii acetylacetone dioxygenase catalyzes the dioxygen-dependent degradation of beta-dicarbonyl compounds ?
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 ?
pentane-2,4-dione + O2 Acinetobacter johnsonii
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 acetate + methylglyoxal
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 ?

Organism

Organism UniProt Comment Textmining
Acinetobacter johnsonii
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information acetylacetone dioxygenase catalyzes the dioxygen-dependent degradation of beta-dicarbonyl compounds Acinetobacter johnsonii ?
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 ?
additional information Dke1 also performs the atypical cleavage of the alpha-keto acid, 4-hydroxyphenylpyruvate, to form 4-hydroxybenzaldehyde as product instead of the homogentisate product found for 4-hydroxyphenylpyruvate with 4-hydroxyphenylpyruvate dioxygenase, EC 1.13.11.27, analysis of the bonding of the alpha-keto acid, 4-hydroxyphenylpyruvate, to ferrous Dke1 using anaerobic Dke1, added ferrous ammonium sulfate, and 4-hydroxyphenylpyruvate at pH 7.0, overview Acinetobacter johnsonii ?
-
 ?
pentane-2,4-dione + O2
-
 Acinetobacter johnsonii acetate + methylglyoxal
-
 ?

Synonyms

Synonyms Comment Organism
acetylacetone dioxygenase
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 Acinetobacter johnsonii
diketone cleaving dioxygenase
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 Acinetobacter johnsonii
Dke1
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 Acinetobacter johnsonii

General Information

General Information Comment Organism
additional information Dke1 also performs the atypical cleavage of the alpha-keto acid, 4-hydroxyphenylpyruvate, to form 4-hydroxybenzaldehyde as product instead of the homogentisate product found for 4-hydroxyphenylpyruvate with 4-hydroxyphenylpyruvate dioxygenase, EC 1.13.11.27, analysis of the bonding of the alpha-keto acid, 4-hydroxyphenylpyruvate, to ferrous Dke1 using anaerobic Dke1, added ferrous ammonium sulfate, and 4-hydroxyphenylpyruvate at pH 7.0, overview. active site was modeling, histidine residues are truncated to methyl imidazole for the model, and constraints imposed by the protein backbone are simulated by fixing the relative positions of the beta-carbons of the backbone. The coordination of the active site is completed with either alpha keto (monoanion) or enolate (dianion) bidentate coordinated 4-hydroxyphenylpyruvate ligand or a monoanionic acetylacetone ligand Acinetobacter johnsonii