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Literature summary for 1.13.11.5 extracted from
- The enzymatic conversion of homogentisic acid to 4-fumarylacetoacetic acid (1951), J. Biol. Chem., 189, 137-149.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cyanide | 3 mM inhibits | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| homogentisate + O2 | homogentisic acid is oxidatively cleaved between carbons 1 and 2 to yield 4-fumarylacetoacetic acid, enzyme requires high oxygen tension for maximal activity | Rattus norvegicus | 4-fumarylacetoacetate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 38 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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