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Literature summary for 1.13.11.40 extracted from

  • Schweiger, D.; Fuerstenberger, G.; Krieg, P.
    Inducible expression of 15-lipoxygenase-2 and 8-lipoxygenase inhibits cell growth via common signaling pathways (2007), J. Lipid Res., 48, 553-564.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression and establishment of a doxycycline-inducible Tet-On gene expression system in the premalignant mouse keratinocyte cell line 308 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information doxycycline-inducible expression in keratinocytes 308 leads to an inhibition of cell growth that is associated with an inhibition of DNA synthesis, as shown by a reduction of 5-bromo-2-deoxy-uridine incorporation up to 46%, doxycycline-induced keratinocytes show increased levels of reactive oxygen species. The antioxidant N-acetyl-L-cysteine and a specific inhibitor of p38 mitogen-activated protein kinase, but not of extracellular signal-regulated kinase 1/2 or c-Jun N-terminal kinase/stress-activated kinases, completely abolish the LOX-induced growth inhibition Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
baicalein
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Mus musculus
-
(5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
-
?
additional information Mus musculus the inducible expression of 8-lipoxygenase inhibits cell growth, 15-LOX-2 and 8-LOX, although displaying different positional specificity, use common signaling pathways to induce growth inhibition in premalignant epithelial cells, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
Mus musculus (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
-
?
additional information the inducible expression of 8-lipoxygenase inhibits cell growth, 15-LOX-2 and 8-LOX, although displaying different positional specificity, use common signaling pathways to induce growth inhibition in premalignant epithelial cells, overview Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
8-lipoxygenase
-
Mus musculus
8-LOX
-
Mus musculus
More the enzyme belongs to the LOX family Mus musculus