Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.34 extracted from

  • Filosa, R.; Peduto, A.; Aparoy, P.; Schaible, A.M.; Luderer, S.; Krauth, V.; Petronzi, C.; Massa, A.; de Rosa, M.; Reddanna, P.; Werz, O.
    Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase (2013), Eur. J. Med. Chem., 67, 269-279.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-(2,4-dihydroxyphenyl)-2-(naphthalen-2-yl)ethanone
-
Homo sapiens
2-(dibenzo[b,d]furan-3-yl)-5-hydroxycyclohexa-2,5-diene-1,4-dione
-
Homo sapiens
2-benzyl-5-hydroxycyclohexa-2,5-diene-1,4-dione
-
Homo sapiens
2-hexyl-5-hydroxycyclohexa-2,5-diene-1,4-dione
-
Homo sapiens
2-hydroxy-5-(3-nitrophenyl)cyclohexa-2,5-diene-1,4-dione
-
Homo sapiens
2-hydroxy-5-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione
-
Homo sapiens
2-hydroxy-5-methoxy-3-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione
-
Homo sapiens
2-methoxy-5-(naphthalen-2-yloxy)cyclohexa-2,5-diene-1,4-dione
-
Homo sapiens
3'-nitrobiphenyl-2,4-diol
-
Homo sapiens
3-(cyclohexylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione
-
Homo sapiens
3-(decahydronaphthalen-2-ylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione
-
Homo sapiens
3-benzyl-2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione
-
Homo sapiens
4-(1-benzothiophen-3-yl)benzene-1,3-diol
-
Homo sapiens
4-(dibenzo[b,d]furan-3-yl)benzene-1,3-diol
-
Homo sapiens
4-(naphthalen-2-ylmethyl)benzene-1,3-diol
-
Homo sapiens
4-(thianthren-2-yl)benzene-1,3-diol
-
Homo sapiens
4-benzylbenzene-1,3-diol
-
Homo sapiens
4-hexylbenzene-1,3-diol
-
Homo sapiens
6-[(4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)methyl]naphthalene-2-carboxylic acid
-
Homo sapiens
biphenyl-2,4-diol
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonic acid + O2
-
Homo sapiens (5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?

Synonyms

Synonyms Comment Organism
5-lipoxygenase
-
Homo sapiens
5-LO
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00028
-
pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 2-methoxy-5-(naphthalen-2-yloxy)cyclohexa-2,5-diene-1,4-dione
0.00058
-
pH not specified in the publication, 37°C, cell-based test system Homo sapiens 3-(decahydronaphthalen-2-ylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione
0.00078
-
pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 2-hydroxy-5-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione
0.0008
-
pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 2-(dibenzo[b,d]furan-3-yl)-5-hydroxycyclohexa-2,5-diene-1,4-dione
0.0014
-
pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 2-hexyl-5-hydroxycyclohexa-2,5-diene-1,4-dione
0.0021
-
pH not specified in the publication, 37°C, cell-based test system Homo sapiens 4-(thianthren-2-yl)benzene-1,3-diol
0.0023
-
value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 2-hydroxy-5-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione
0.0023
-
value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 4-(naphthalen-2-ylmethyl)benzene-1,3-diol
0.0028
-
pH not specified in the publication, 37°C, cell-free based test system Homo sapiens biphenyl-2,4-diol
0.0028
-
value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 4-hexylbenzene-1,3-diol
0.003
-
pH not specified in the publication, 37°C, cell-based test system Homo sapiens 2-hexyl-5-hydroxycyclohexa-2,5-diene-1,4-dione
0.0032
-
pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 4-(thianthren-2-yl)benzene-1,3-diol
0.0042
-
pH not specified in the publication, 37°C, cell-based test system Homo sapiens biphenyl-2,4-diol
0.0046
-
pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 2-hydroxy-5-(3-nitrophenyl)cyclohexa-2,5-diene-1,4-dione
0.0046
-
pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 4-hexylbenzene-1,3-diol
0.0063
-
pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 4-(dibenzo[b,d]furan-3-yl)benzene-1,3-diol
0.0067
-
pH not specified in the publication, 37°C, cell-based test system Homo sapiens 2-methoxy-5-(naphthalen-2-yloxy)cyclohexa-2,5-diene-1,4-dione
0.0068
-
pH not specified in the publication, 37°C, cell-based test system Homo sapiens 1-(2,4-dihydroxyphenyl)-2-(naphthalen-2-yl)ethanone
0.0074
-
pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 4-(naphthalen-2-ylmethyl)benzene-1,3-diol
0.009
-
pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 4-benzylbenzene-1,3-diol
0.009
-
pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 6-[(4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)methyl]naphthalene-2-carboxylic acid
0.01
-
value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 3-(cyclohexylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione
0.01
-
value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 2-(dibenzo[b,d]furan-3-yl)-5-hydroxycyclohexa-2,5-diene-1,4-dione
0.01
-
value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 2-benzyl-5-hydroxycyclohexa-2,5-diene-1,4-dione
0.01
-
value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 2-hydroxy-5-(3-nitrophenyl)cyclohexa-2,5-diene-1,4-dione
0.01
-
value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 2-hydroxy-5-methoxy-3-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione
0.01
-
value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 3-benzyl-2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione
0.01
-
value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 4-(1-benzothiophen-3-yl)benzene-1,3-diol
0.01
-
value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 4-(dibenzo[b,d]furan-3-yl)benzene-1,3-diol
0.01
-
value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 4-benzylbenzene-1,3-diol
0.01
-
value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 6-[(4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)methyl]naphthalene-2-carboxylic acid
0.01
-
value above, pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 3-(cyclohexylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione
0.01
-
value above, pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 1-(2,4-dihydroxyphenyl)-2-(naphthalen-2-yl)ethanone
0.01
-
value above, pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 2-benzyl-5-hydroxycyclohexa-2,5-diene-1,4-dione
0.01
-
value above, pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 2-hydroxy-5-methoxy-3-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione
0.01
-
value above, pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 3'-nitrobiphenyl-2,4-diol
0.01
-
value above, pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 3-benzyl-2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione
0.01
-
value above, pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 4-(1-benzothiophen-3-yl)benzene-1,3-diol
0.01
-
value above,pH not specified in the publication, 37°C, cell-based test system Homo sapiens 3'-nitrobiphenyl-2,4-diol
0.011
-
pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 3-(decahydronaphthalen-2-ylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione