Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(2,4-dihydroxyphenyl)-2-(naphthalen-2-yl)ethanone | - |
Homo sapiens | |
2-(dibenzo[b,d]furan-3-yl)-5-hydroxycyclohexa-2,5-diene-1,4-dione | - |
Homo sapiens | |
2-benzyl-5-hydroxycyclohexa-2,5-diene-1,4-dione | - |
Homo sapiens | |
2-hexyl-5-hydroxycyclohexa-2,5-diene-1,4-dione | - |
Homo sapiens | |
2-hydroxy-5-(3-nitrophenyl)cyclohexa-2,5-diene-1,4-dione | - |
Homo sapiens | |
2-hydroxy-5-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione | - |
Homo sapiens | |
2-hydroxy-5-methoxy-3-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione | - |
Homo sapiens | |
2-methoxy-5-(naphthalen-2-yloxy)cyclohexa-2,5-diene-1,4-dione | - |
Homo sapiens | |
3'-nitrobiphenyl-2,4-diol | - |
Homo sapiens | |
3-(cyclohexylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione | - |
Homo sapiens | |
3-(decahydronaphthalen-2-ylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione | - |
Homo sapiens | |
3-benzyl-2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione | - |
Homo sapiens | |
4-(1-benzothiophen-3-yl)benzene-1,3-diol | - |
Homo sapiens | |
4-(dibenzo[b,d]furan-3-yl)benzene-1,3-diol | - |
Homo sapiens | |
4-(naphthalen-2-ylmethyl)benzene-1,3-diol | - |
Homo sapiens | |
4-(thianthren-2-yl)benzene-1,3-diol | - |
Homo sapiens | |
4-benzylbenzene-1,3-diol | - |
Homo sapiens | |
4-hexylbenzene-1,3-diol | - |
Homo sapiens | |
6-[(4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)methyl]naphthalene-2-carboxylic acid | - |
Homo sapiens | |
biphenyl-2,4-diol | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonic acid + O2 | - |
Homo sapiens | (5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5-lipoxygenase | - |
Homo sapiens |
5-LO | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00028 | - |
pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 2-methoxy-5-(naphthalen-2-yloxy)cyclohexa-2,5-diene-1,4-dione | |
0.00058 | - |
pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 3-(decahydronaphthalen-2-ylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione | |
0.00078 | - |
pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 2-hydroxy-5-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione | |
0.0008 | - |
pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 2-(dibenzo[b,d]furan-3-yl)-5-hydroxycyclohexa-2,5-diene-1,4-dione | |
0.0014 | - |
pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 2-hexyl-5-hydroxycyclohexa-2,5-diene-1,4-dione | |
0.0021 | - |
pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 4-(thianthren-2-yl)benzene-1,3-diol | |
0.0023 | - |
value above, pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 2-hydroxy-5-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione | |
0.0023 | - |
value above, pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 4-(naphthalen-2-ylmethyl)benzene-1,3-diol | |
0.0028 | - |
pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | biphenyl-2,4-diol | |
0.0028 | - |
value above, pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 4-hexylbenzene-1,3-diol | |
0.003 | - |
pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 2-hexyl-5-hydroxycyclohexa-2,5-diene-1,4-dione | |
0.0032 | - |
pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 4-(thianthren-2-yl)benzene-1,3-diol | |
0.0042 | - |
pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | biphenyl-2,4-diol | |
0.0046 | - |
pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 2-hydroxy-5-(3-nitrophenyl)cyclohexa-2,5-diene-1,4-dione | |
0.0046 | - |
pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 4-hexylbenzene-1,3-diol | |
0.0063 | - |
pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 4-(dibenzo[b,d]furan-3-yl)benzene-1,3-diol | |
0.0067 | - |
pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 2-methoxy-5-(naphthalen-2-yloxy)cyclohexa-2,5-diene-1,4-dione | |
0.0068 | - |
pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 1-(2,4-dihydroxyphenyl)-2-(naphthalen-2-yl)ethanone | |
0.0074 | - |
pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 4-(naphthalen-2-ylmethyl)benzene-1,3-diol | |
0.009 | - |
pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 4-benzylbenzene-1,3-diol | |
0.009 | - |
pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 6-[(4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)methyl]naphthalene-2-carboxylic acid | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 3-(cyclohexylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 2-(dibenzo[b,d]furan-3-yl)-5-hydroxycyclohexa-2,5-diene-1,4-dione | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 2-benzyl-5-hydroxycyclohexa-2,5-diene-1,4-dione | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 2-hydroxy-5-(3-nitrophenyl)cyclohexa-2,5-diene-1,4-dione | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 2-hydroxy-5-methoxy-3-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 3-benzyl-2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 4-(1-benzothiophen-3-yl)benzene-1,3-diol | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 4-(dibenzo[b,d]furan-3-yl)benzene-1,3-diol | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 4-benzylbenzene-1,3-diol | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 6-[(4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)methyl]naphthalene-2-carboxylic acid | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 3-(cyclohexylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 1-(2,4-dihydroxyphenyl)-2-(naphthalen-2-yl)ethanone | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 2-benzyl-5-hydroxycyclohexa-2,5-diene-1,4-dione | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 2-hydroxy-5-methoxy-3-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 3'-nitrobiphenyl-2,4-diol | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 3-benzyl-2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione | |
0.01 | - |
value above, pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 4-(1-benzothiophen-3-yl)benzene-1,3-diol | |
0.01 | - |
value above,pH not specified in the publication, 37°C, cell-based test system | Homo sapiens | 3'-nitrobiphenyl-2,4-diol | |
0.011 | - |
pH not specified in the publication, 37°C, cell-free based test system | Homo sapiens | 3-(decahydronaphthalen-2-ylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione |