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Literature summary for 1.13.11.34 extracted from

  • Radmark, O.; Samuelsson, B.
    Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis (2010), Biochem. Biophys. Res. Commun., 396, 105-110.
    View publication on PubMed
Search for more literature for 1.13.11.34

Activating Compound

Activating Compound Comment Organism Structure
5-lipoxygenase activating protein 5-lipoxygenase activating protein is crucial for conversion of endogenous substrate by 5LO 5-lipoxygenase activating protein also stimulates the utilization of exogenous arachidonic acid, and greatly (190fold) stimulates utilization of (5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
hyperforin
-
 Homo sapiens
MK-886
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol in resting cells, 5LO resides either in the cytosol (e.g. in neutrophils, eosinophils, peritoneal macrophages) or in a nuclear soluble compartment associated with chromatin (e.g. in alveolar macrophages, Langerhans cells, basophilic leukemia cells) Homo sapiens 5829
-
nucleus in activated cells Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+ is required for 5LO activity, the enzyme contains two Ca2+, full activation is reached at 0.004-0.01 mM Ca2+ Homo sapiens
Fe the iron acts as electron acceptor and donor, during hydrogen abstraction and peroxide formation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid + O2 Homo sapiens
-
 ?
-
 ?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Homo sapiens efficient LTA4 formation of 5LO requires both phosphatidyl choline and coactosin-like protein leukotriene A4 + H2O
-
 ?
arachidonate + O2 Homo sapiens
-
 (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein 5LO can be phosphorylated at three residues: Ser-271 (by MAP-KAP kinases), Ser-663 (by ERK2), and Ser-523 (by protein kinase A catalytic subunit) Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
 Homo sapiens
-
dendritic cell
-
 Homo sapiens
-
eosinophil
-
 Homo sapiens
-
foam cell foam cell of human atherosclerotic tissue Homo sapiens
-
macrophage
-
 Homo sapiens
-
mast cell
-
 Homo sapiens
-
monocyte
-
 Homo sapiens
-
neutrophil
-
 Homo sapiens
-
reticulocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid + O2
-
 Homo sapiens ?
-
 ?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate efficient LTA4 formation of 5LO requires both phosphatidyl choline and coactosin-like protein Homo sapiens leukotriene A4 + H2O
-
 ?
arachidonate + O2
-
 Homo sapiens (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
5-lipoxygenase
-
 Homo sapiens
5LO
-
 Homo sapiens
LTA4 synthase
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism 5-lipoxygenase is a key enzyme in leukotriene biosynthesis Homo sapiens