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Literature summary for 1.13.11.34 extracted from
- Methyl jasmonate induced apoptosis in human prostate carcinoma cells via 5-lipoxygenase dependent pathway (2007), J. Exp. Ther. Oncol., 6, 267-277.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| MK886 | specific inhibitor of 5-hydroperoxyeicosatetraenoic acid synthesis by the enzyme | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-hydroperoxyeicosatetraenoic acid | Homo sapiens | - |
leukotriene A4 + H2O | is unstable and metabolized to leukotriene B4 | ? | |
| arachidonic acid + O2 | Homo sapiens | - |
5-hydroperoxyeicosatetraenoic acid | - |
? | |
| additional information | Homo sapiens | the enzyme, catalyzing the key step in leukotriene biosynthesis, interacts with methyl jasmonate, which is probably involved in the anticarcinogenic activity of methyl jasmonate inducing apoptosis, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| DU-145 cell | - |
Homo sapiens | - |
| PC-3 cell | - |
Homo sapiens | - |
| prostate adenocarcinoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-hydroperoxyeicosatetraenoic acid | - |
Homo sapiens | leukotriene A4 + H2O | - |
? | |
| 5-hydroperoxyeicosatetraenoic acid | - |
Homo sapiens | leukotriene A4 + H2O | is unstable and metabolized to leukotriene B4 | ? | |
| arachidonic acid + O2 | - |
Homo sapiens | 5-hydroperoxyeicosatetraenoic acid | - |
? | |
| additional information | the enzyme, catalyzing the key step in leukotriene biosynthesis, interacts with methyl jasmonate, which is probably involved in the anticarcinogenic activity of methyl jasmonate inducing apoptosis, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5-lipoxygenase | - |
Homo sapiens |
| 5-LOX | - |
Homo sapiens |
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