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Literature summary for 1.13.11.34 extracted from
- Cell type-dependent activation of 5-lipoxygenase by arachidonic acid (2003), J. Leukocyte Biol., 73, 191-200.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 5-lipoxygenase product formation in arachidonic acid-stimulated polymorphonuclear leukocytes is independent of Ca2+ | Rattus norvegicus |  |
| Ca2+ | 5-lipoxygenase product formation in arachidonic acid-stimulated polymorphonuclear leukocytes is independent of Ca2+. Ca2+ and 5-lipoxygenase phosphorylation seem to be required for arachidonic acid-induced 5-lipoxygenase product formation | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | key enzyme in the biosynthesis of proinflammatory leukotrienes | ? | - |
? | |
| additional information | Rattus norvegicus | key enzyme in the biosynthesis of proinflammatory leukotrienes | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | Ca2+ and 5-lipoxygenase phosphorylation seem to be required for arachidonic acid-induced 5-lipoxygenase product formation | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
| polymorphonuclear leukocyte | - |
Homo sapiens | - |
| RBL-1 cell | basophilic leukemia cell | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | key enzyme in the biosynthesis of proinflammatory leukotrienes | Homo sapiens | ? | - |
? | |
| additional information | key enzyme in the biosynthesis of proinflammatory leukotrienes | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5-LO | - |
Homo sapiens |
| 5-LO | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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