Application | Comment | Organism |
---|---|---|
drug development | systemic delivery of cholesterol-tagged siRNAs targeting 12/15-LO has renoprotective effects under diabetic conditions and therefore can be a novel therapeutic approach for diabetic nephropathy | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
siRNA | cholesterol-tagged siRNAs targeting mouse leukocyte 12/15-LO reduce 12/15-LO expression in the kidney and confer beneficial effects on diabetes-induced changes in glomerular structure and ECM accumulation | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
DBA/2J mice | - |
Mus musculus DBA/2J | - |
DBA/2J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mus musculus | - |
kidney | - |
Mus musculus | - |
leukocyte | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
spleen | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
12/15-lipoxygenase | - |
Mus musculus |
12/15-LO | - |
Mus musculus |