Literature summary for 1.13.11.33 extracted from

Russell, W.R.; Scobbie, L.; Duthie, G.G.; Chesson, A.
Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids (2008), Bioorg. Med. Chem., 16, 4589-4593.

Search for more literature for 1.13.11.33

Inhibitors

Inhibitors	Comment	Organism	Structure
2,3-Dihydroxybenzoic acid	47.7% inhibition at 0.015 mM, active site binding structure	Glycine max
2,4-dihydroxybenzoic acid	49.9% inhibition at 0.015 mM, active site binding structure	Glycine max
2,5-dihydroxybenzoic acid	21.2% inhibition at 0.015 mM, active site binding structure	Glycine max
2-hydroxybenzoic acid	46.0% inhibition at 0.015 mM, active site binding structure	Glycine max
3,4,5-Trihydroxybenzoic acid	60.5% inhibition at 0.015 mM, active site binding structure	Glycine max
3,4-dihydroxybenzoic acid	51.6% inhibition at 0.015 mM, active site binding structure; 73.3% inhibition at 0.015 mM, active site binding structure	Glycine max
3,5-Dihydroxybenzoic acid	58.1% inhibition at 0.015 mM, active site binding structure	Glycine max
3-Hydroxybenzoic acid	47.6% inhibition at 0.015 mM, active site binding structure	Glycine max
4-hydroxy-3-methoxybenzoic acid	45.4% inhibition at 0.015 mM, active site binding structure	Glycine max
4-hydroxybenzoic acid	47.0% inhibition at 0.015 mM, active site binding structure	Glycine max
benzoic acid	48.4% inhibition at 0.015 mM, active site binding structure	Glycine max
caffeic acid	36.2% inhibition at 0.015 mM	Glycine max
additional information	no inhibition by 2,6-dihydroxybenzoic acid	Glycine max

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
arachidonate + O2	Glycine max	-	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate	-	?

Organism

Organism	UniProt	Comment	Textmining
Glycine max	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	-	Glycine max	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate	-	?

Synonyms

Synonyms	Comment	Organism
15-lipoxygenase	-	Glycine max

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Release 2023.1 (January 2023)