Cloned (Comment) | Organism |
---|---|
gene ALOX15, DNA and amino acid sequence determination and analysis of wild-type and mutant T560M, promoter sequence analysis, genotyping, overview, expression of wild-type and mutant enzymes in Escherichia coli and HEK-297 cells, the mutant shows a low expression level in both systems compared to the wild-type enzyme | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
T560M | naturally occurring enzyme mutant, the mutant shows 20fold reduced catalytic activity, genotyping using 12974 samples, the haplotypes show increased risk of coronary artery disease compared to non-carriers, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16050 | gene ALOX15 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | a bifunctional enzyme exhibiting 12-LO and 15-LO activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
12/15-lipoxygenase | - |
Homo sapiens |
12/15-LO | - |
Homo sapiens |