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Literature summary for 1.13.11.33 extracted from

  • Teklu, S.; Gundersen, L.L.; Larsen, T.; Malterud, K.E.; Rise, F.
    Indolizine 1-sulfonates as potent inhibitors of 15-lipoxygenase from soybeans (2005), Bioorg. Med. Chem., 13, 3127-3139.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(((2,4,6-trimethylphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.017 mM Glycine max
1-(((2,4-dimethoxyphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.027 mM Glycine max
1-(((2,5-dimethoxyphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.015 mM Glycine max
1-(((2-methyl)ethylsulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.042 mM Glycine max
1-(((2-methyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.022 mM Glycine max
1-(((2-thienyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.021 mM Glycine max
1-(((3,4-dimethoxyphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.019 mM Glycine max
1-(((3-thienyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.023 mM Glycine max
1-(((4-(2-methylethyl)phenl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.016 mM Glycine max
1-(((4-chlorophenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.022 mM Glycine max
1-(((4-methoxyphenyl)sulfonyl)oxy)-2,3-bis(4-methylphenyl)-7-indolizinecarbonitrile IC50: 0.025 mM Glycine max
1-(((4-methoxyphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.025 mM Glycine max
1-(((4-methylphenyl)sulfonyl)oxy)-2,3-bis(4-chlorophenyl)-7-indolizinecarbonitrile IC50: 0.2 mM Glycine max
1-(((4-methylphenyl)sulfonyl)oxy)-2,3-bis(4-fluorophenyl)-7-indolizinecarbonitrile IC50: 0.22 mM Glycine max
1-(((4-methylphenyl)sulfonyl)oxy)-2,3-bis(4-methoxyphenyl)-7-indolizinecarbonitrile IC50: 0.024 mM Glycine max
1-(((4-methylphenyl)sulfonyl)oxy)-2,3-bis(4-methylphenyl)-7-indolizinecarbonitrile IC50: 0.2 mM Glycine max
1-(((4-methylphenyl)sulfonyl)oxy)-2,3-dibutyl-7-indolizinecarbonitrile IC50: 0.03 mM Glycine max
1-(((4-methylphenyl)sulfonyl)oxy)-2,3-diethyl-7-indolizinecarbonitrile IC50: 0.029 mM Glycine max
1-(((4-methylphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarboxaldehyde IC50: 0.02 mM Glycine max
1-(((4-methylphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinylethanone IC50: 0.023 mM Glycine max
1-(((4-methysulfonyllphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.024 mM Glycine max
1-(((4-trifluoromethylphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.023 mM Glycine max
1-((4-methylphenyl)sulfonyl)2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.029 mM Glycine max
1-((butylsulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.028 mM Glycine max
1-((methylsulfonyl)oxy)-2,3-diphenyl-7-indolizine-carbonitrile IC50: 0.022 mM Glycine max
1-((N,N-dimethylaminosulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.025 mM Glycine max
1-((phenylsulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile IC50: 0.024 mM Glycine max
2,3-bis(4-chlorophenyl)-7-indolizinecarbonitrile IC50: 0.033 mM Glycine max
2,3-bis(4-fluorophenyl)-7-indolizinecarbonitrile IC50: 0.03 mM Glycine max
2,3-bis(4-methylphenyl)-7-indolizinecarbonitrile IC50: 0.027 mM Glycine max
2,3-diphenyl-1-indolizinol tosylate IC50: 0.025 mM Glycine max
6,7-diphenylpyrrolo[1,2-a]pyrimidin-8-ol tosylate IC50: 0.015 mM Glycine max
6,7-diphenylpyrrolo[1,2-c]pyrimidin-5-ol tosylate IC50: 0.022 mM Glycine max
7-(1,1-dimethylethyl)-2,3-diphenyl-1-indolizinol tosylate IC50: 0.022 mM Glycine max

Organism

Organism UniProt Comment Textmining
Glycine max
-
-
-

Synonyms

Synonyms Comment Organism
15-LO
-
Glycine max

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.015
-
IC50: 0.015 mM Glycine max 1-(((2,5-dimethoxyphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.015
-
IC50: 0.015 mM Glycine max 6,7-diphenylpyrrolo[1,2-a]pyrimidin-8-ol tosylate
0.016
-
IC50: 0.016 mM Glycine max 1-(((4-(2-methylethyl)phenl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.017
-
IC50: 0.017 mM Glycine max 1-(((2,4,6-trimethylphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.019
-
IC50: 0.019 mM Glycine max 1-(((3,4-dimethoxyphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.02
-
IC50: 0.02 mM Glycine max 1-(((4-methylphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarboxaldehyde
0.021
-
IC50: 0.021 mM Glycine max 1-(((2-thienyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.022
-
IC50: 0.022 mM Glycine max 7-(1,1-dimethylethyl)-2,3-diphenyl-1-indolizinol tosylate
0.022
-
IC50: 0.022 mM Glycine max 1-((methylsulfonyl)oxy)-2,3-diphenyl-7-indolizine-carbonitrile
0.022
-
IC50: 0.022 mM Glycine max 1-(((2-methyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.022
-
IC50: 0.022 mM Glycine max 1-(((4-chlorophenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.022
-
IC50: 0.022 mM Glycine max 6,7-diphenylpyrrolo[1,2-c]pyrimidin-5-ol tosylate
0.023
-
IC50: 0.023 mM Glycine max 1-(((4-methylphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinylethanone
0.023
-
IC50: 0.023 mM Glycine max 1-(((3-thienyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.023
-
IC50: 0.023 mM Glycine max 1-(((4-trifluoromethylphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.024
-
IC50: 0.024 mM Glycine max 1-(((4-methylphenyl)sulfonyl)oxy)-2,3-bis(4-methoxyphenyl)-7-indolizinecarbonitrile
0.024
-
IC50: 0.024 mM Glycine max 1-((phenylsulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.024
-
IC50: 0.024 mM Glycine max 1-(((4-methysulfonyllphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.025
-
IC50: 0.025 mM Glycine max 2,3-diphenyl-1-indolizinol tosylate
0.025
-
IC50: 0.025 mM Glycine max 1-((N,N-dimethylaminosulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.025
-
IC50: 0.025 mM Glycine max 1-(((4-methoxyphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.025
-
IC50: 0.025 mM Glycine max 1-(((4-methoxyphenyl)sulfonyl)oxy)-2,3-bis(4-methylphenyl)-7-indolizinecarbonitrile
0.027
-
IC50: 0.027 mM Glycine max 1-(((2,4-dimethoxyphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.027
-
IC50: 0.027 mM Glycine max 2,3-bis(4-methylphenyl)-7-indolizinecarbonitrile
0.028
-
IC50: 0.028 mM Glycine max 1-((butylsulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.029
-
IC50: 0.029 mM Glycine max 1-(((4-methylphenyl)sulfonyl)oxy)-2,3-diethyl-7-indolizinecarbonitrile
0.029
-
IC50: 0.029 mM Glycine max 1-((4-methylphenyl)sulfonyl)2,3-diphenyl-7-indolizinecarbonitrile
0.03
-
IC50: 0.03 mM Glycine max 1-(((4-methylphenyl)sulfonyl)oxy)-2,3-dibutyl-7-indolizinecarbonitrile
0.03
-
IC50: 0.03 mM Glycine max 2,3-bis(4-fluorophenyl)-7-indolizinecarbonitrile
0.033
-
IC50: 0.033 mM Glycine max 2,3-bis(4-chlorophenyl)-7-indolizinecarbonitrile
0.042
-
IC50: 0.042 mM Glycine max 1-(((2-methyl)ethylsulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile
0.2
-
IC50: 0.2 mM Glycine max 1-(((4-methylphenyl)sulfonyl)oxy)-2,3-bis(4-chlorophenyl)-7-indolizinecarbonitrile
0.2
-
IC50: 0.2 mM Glycine max 1-(((4-methylphenyl)sulfonyl)oxy)-2,3-bis(4-methylphenyl)-7-indolizinecarbonitrile
0.22
-
IC50: 0.22 mM Glycine max 1-(((4-methylphenyl)sulfonyl)oxy)-2,3-bis(4-fluorophenyl)-7-indolizinecarbonitrile