Literature summary for 1.13.11.31 extracted from

Pallast, S.; Arai, K.; Wang, X.; Lo, E.H.; van Leyen, K.
12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress (2009), J. Neurochem., 111, 882-889.

Search for more literature for 1.13.11.31

Application

Application	Comment	Organism
drug development	inhibition of 12/15-LOX provides robust protection against cell death preventing mitochondrial damage in oxidative stress-related brain injury	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
AA861	prevents cell death, the 12/15-LOX inhibitor and the proteasome protect against exogenous glutamate, but not by preventing glutathione depletion. LOX inhibition, but not proteasome inhibition, reduces oxidative stress in glutamate-treated HT22 cells. The mitochondrial membrane potential is protected by coinhibition with baicalien	Mus musculus
baicalein	prevents cell death, the 12/15-LOX inhibitor and the proteasome protect against exogenous glutamate, but not by preventing glutathione depletion. LOX inhibition, but not proteasome inhibition, reduces oxidative stress in glutamate-treated HT22 cells. The mitochondrial membrane potential is protected by coinhibition with AA861	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HT-22 cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
12/15-LOX	-	Mus musculus
2/15-lipoxygenase	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	12/15-LOX is the central executioner in an oxidative stress-related neuronal death program. In neuronal HT22 cells subjected to glutamate-induced oxidative stress, 12/15-LOX damages mitochondria, which represents the committed step that condemns the cell to die. Mitochondria incubated with 12/15-LOX generate reactive oxygen species	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)