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Literature summary for 1.13.11.31 extracted from

  • Kayama, Y.; Minamino, T.; Toko, H.; Sakamoto, M.; Shimizu, I.; Takahashi, H.; Okada, S.; Tateno, K.; Moriya, J.; Yokoyama, M.; Nojima, A.; Yoshimura, M.; Egashira, K.; Aburatani, H.; Komuro, I.
    Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure (2009), J. Exp. Med., 206, 1565-1574.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development cardiac 12/15-LOX is involved in the development of heart failure and inhibition of 12/15-LOX may be a novel treatment for this condition Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
transgenic mice overexpressing 12/15-LOX in cardiomyocytes Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
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Mus musculus
-

Synonyms

Synonyms Comment Organism
12/15 lipoxygenase
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Mus musculus
12/15-LOX
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Mus musculus
Alox15
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Mus musculus

Expression

Organism Comment Expression
Mus musculus 12/15-LOX is markedly upregulated in heart failure, cardiac expression is upregulated during pressure overload up

General Information

General Information Comment Organism
physiological function increased expression of 2/15-LOX causes heart failure. 2/15-LOX induces cardiac inflammation. Alox15 transgenic mice develop systolic dysfunction. Cardiac fibrosis increases in Alox15 transgenic mice with advancing age and is associated with the infiltration of macrophages. Cardiac expression of monocyte chemoattractant protein 1 is up-regulated in Alox15 transgenic mice compared with wild-type mice. Disruption of 12/15-LOX significantly reduces cardiac monocyte chemoattractant protein-1 expression and macrophage infiltration, thereby improving systolic dysfunction induced by chronic pressure overload Mus musculus