Cloned (Comment) | Organism |
---|---|
expression of His-tagged enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-alkyl benzopyran-4-ones | weak inhibition | Homo sapiens | |
2-alkyl-6-hydroxy-4-H-benzopyran-4-one | weak inhibition | Homo sapiens | |
3'-chloro-7,8-dihydroxyisoflavone | - |
Homo sapiens | |
4',6,7-trihydroxyisoflavan | - |
Homo sapiens | |
4',6,7-trihydroxyisoflavanone | - |
Homo sapiens | |
4',6,7-trihydroxyisoflavone | - |
Homo sapiens | |
4'-chloro-7,8-dihydroxyisoflavone | - |
Homo sapiens | |
6,7-dihydroxy-3',4'-methylenedioxyisoflavan | - |
Homo sapiens | |
6,7-dihydroxy-3',4'-methylenedioxyisoflavone | - |
Homo sapiens | |
6,7-dihydroxy-3'-methylisoflavan | - |
Homo sapiens | |
6,7-dihydroxy-3'-methylisoflavanone | - |
Homo sapiens | |
6,7-dihydroxy-4'-methoxyisoflavan | - |
Homo sapiens | |
6,7-dihydroxy-4'-methoxyisoflavanone | - |
Homo sapiens | |
6,7-dihydroxy-4'-methoxyisoflavone | - |
Homo sapiens | |
6,7-dihydroxy-4'-nitroisoflavone | - |
Homo sapiens | |
7,8-dihydroxy-3',4'-dimethoxyisoflavan | - |
Homo sapiens | |
7,8-dihydroxy-3'-methylisoflavone | - |
Homo sapiens | |
7,8-dihydroxy-3'-trifluoromethylisoflavone | - |
Homo sapiens | |
7,8-dihydroxy-4'-methoxyisoflavan | - |
Homo sapiens | |
7,8-dihydroxy-4'-methylisoflavan | - |
Homo sapiens | |
7,8-dihydroxy-4'-methylisoflavone | - |
Homo sapiens | |
7,8-dihydroxyisoflavone | - |
Homo sapiens | |
7-hydroxy-H-benzopyran-4-one derivatives | weak inhibition | Homo sapiens | |
H-benzopyran-4-one derivatives | weak inhibition | Homo sapiens | |
additional information | comparison of structural requirements for flavonoid inhibitory potency and selectivity against platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2, the two latter belong to EC 1.13.11.33, overview, catechols are essential for high potency, isoflavones and isoflavanones tend to select against 12-hLO, isoflavans tend to select against isozyme 15-hLO-1, but few flavonoids target isozyme 15-hLO-2, molecular modeling analysis, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | Homo sapiens | - |
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme 12-hLO | - |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged enzyme | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | isozyme 12-hLO | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
12-hLO | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00048 | - |
pH 7.5, 22°C | Homo sapiens | 4'-chloro-7,8-dihydroxyisoflavone | |
0.00062 | - |
pH 7.5, 22°C | Homo sapiens | 7,8-dihydroxy-3'-trifluoromethylisoflavone | |
0.00078 | - |
pH 7.5, 22°C | Homo sapiens | 3'-chloro-7,8-dihydroxyisoflavone | |
0.0016 | - |
pH 7.5, 22°C | Homo sapiens | 6,7-dihydroxy-4'-methoxyisoflavanone | |
0.0016 | - |
pH 7.5, 22°C | Homo sapiens | 7,8-dihydroxy-4'-methylisoflavone | |
0.0036 | - |
pH 7.5, 22°C | Homo sapiens | 7,8-dihydroxy-3'-methylisoflavone | |
0.0038 | - |
pH 7.5, 22°C | Homo sapiens | 4',6,7-trihydroxyisoflavanone | |
0.0058 | - |
pH 7.5, 22°C | Homo sapiens | 6,7-dihydroxy-4'-nitroisoflavone | |
0.0064 | - |
pH 7.5, 22°C | Homo sapiens | 7,8-dihydroxyisoflavone | |
0.0076 | - |
pH 7.5, 22°C | Homo sapiens | 6,7-dihydroxy-4'-methoxyisoflavan | |
0.0087 | - |
pH 7.5, 22°C | Homo sapiens | 4',6,7-trihydroxyisoflavone | |
0.011 | - |
pH 7.5, 22°C | Homo sapiens | 6,7-dihydroxy-3',4'-methylenedioxyisoflavan | |
0.014 | - |
pH 7.5, 22°C | Homo sapiens | 6,7-dihydroxy-3'-methylisoflavanone | |
0.015 | - |
pH 7.5, 22°C | Homo sapiens | 6,7-dihydroxy-3'-methylisoflavan | |
0.017 | - |
pH 7.5, 22°C | Homo sapiens | 4',6,7-trihydroxyisoflavan | |
0.026 | - |
pH 7.5, 22°C | Homo sapiens | 7,8-dihydroxy-4'-methoxyisoflavan | |
0.07 | - |
pH 7.5, 22°C | Homo sapiens | 7,8-dihydroxy-4'-methylisoflavan | |
0.1 | - |
above, pH 7.5, 22°C | Homo sapiens | 7,8-dihydroxy-3',4'-dimethoxyisoflavan | |
0.1 | - |
above, pH 7.5, 22°C | Homo sapiens | 6,7-dihydroxy-4'-methoxyisoflavone | |
0.1 | - |
above, pH 7.5, 22°C | Homo sapiens | 6,7-dihydroxy-3',4'-methylenedioxyisoflavone |