Inhibitors | Comment | Organism | Structure |
---|---|---|---|
baicalein | inhibits the enzyme and its binding to cytoplasmic muscle fibrills, overview | Homo sapiens | |
esculetine | inhibits the enzyme and its binding to cytoplasmic muscle fibrills, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | primarily associated with cytoplasmic vascular smooth muscle cell muscle fibrils binding to alpha-actin, a component of the cytoplasmic myofilaments, not associated with 12-LO serine or tyrosine phosphorylation, overview, the binding is induced by angiotensin II | Homo sapiens | 5737 | - |
additional information | subcellular distribution analysis, overview | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | Homo sapiens | the platelet-type 12S-lipoxygenase isozyme is involved in angiotensin-II induced signaling in vascular smooth muscle cells | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
platelet-type 12S-lipoxygenase isozyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
umbilical artery | vascular smooth muscle, the enzyme associates with alpha-actin fibers | Homo sapiens | - |
vascular smooth muscle | umbilical artery, the enzyme associates with alpha-actin fibers | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | - |
? | |
arachidonate + O2 | the platelet-type 12S-lipoxygenase isozyme is involved in angiotensin-II induced signaling in vascular smooth muscle cells | Homo sapiens | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
12-LO | - |
Homo sapiens |
12S-lipoxygenase | - |
Homo sapiens |