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Literature summary for 1.13.11.31 extracted from
- Arachidonate 12-lipoxygenase purified from porcine leukocytes by immunoaffinity chromatography and its reactivity with hydroperoxyeicosatetraenoic acids (1986), J. Biol. Chem., 261, 16714-16721.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| arachidonic acid | substrate inhibition | Sus scrofa |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Sus scrofa | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 72000 | - |
x * 72000, SDS-PAGE | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukocyte | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Sus scrofa |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, 1 month | Sus scrofa |
| 4°C, half-life: 24 h, markedly stabilized by 0.02 mM Fe2+ | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 15(S)-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid + O2 | - |
Sus scrofa | additional information | (8S,15S)-dihydroperoxy-5Z,9E,11Z,13E-eicosatetraenoic acid + (14R,15S)-erythro-dihydroperoxy-5Z,8Z,10E,12E-eicosatetraenoic acid | ? | |
| 5(S)-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid + O2 | - |
Sus scrofa | 5,12-(5S,12S)-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + 5,12-(5S,15S)-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid | - |
? | |
| arachidonate + O2 | i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid | Sus scrofa | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? | |
| gamma-linolenic acid + O2 | - |
Sus scrofa | 10-hydroxy-octadeca-6Z,8E,12Z-trienoic acid | - |
? | |
| linoleic acid + O2 | - |
Sus scrofa | 13(S)-hydroperoxy-9Z,11E-octadecadienoic acid | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 72000, SDS-PAGE | Sus scrofa |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 4 | - |
half-life: 24 h | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Sus scrofa |
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