Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.27 extracted from

  • Yang, C.; Pflugrath, J.W.; Camper, D.L.; Foster, M.L.; Pernich, D.J.; Walsh, T.A.
    Structural basis for herbicidal inhibitor selectivity revealed by comparison of crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases (2004), Biochemistry, 43, 10414-10423.
    View publication on PubMed
Search for more literature for 1.13.11.27

Crystallization (Commentary)

Crystallization (Comment) Organism
with and without inhibitors 1-(1,1-dimethylethyl)-5-hydroxy-4-(3-(4-(methoxy)phenyl)-2-methyl-4-(methylsulfonyl)benzoyl)pyrazole or [1-tert-butyl-3-(2,4-dichlorophenyl)-5-hydroxy-1H-pyrazol-4-yl][2-chloro-4-(methylsulfonyl)phenyl]methanone Rattus norvegicus
with and without inhibitors [1-tert-butyl-3-(2,4-dichlorophenyl)-5-hydroxy-1H-pyrazol-4-yl][2-chloro-4-(methylsulfonyl)phenyl]methanone or 1-(1,1-dimethylethyl)-5-hydroxy-4-(3-(4-(methoxy)phenyl)-2-methyl-4-(methylsulfonyl)benzoyl)pyrazole Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
1-(1,1-dimethylethyl)-5-hydroxy-4-(3-(4-(methoxy)phenyl)-2-methyl-4-(methylsulfonyl)benzoyl)pyrazole 50% inhibition at 7 nM Arabidopsis thaliana
1-(1,1-dimethylethyl)-5-hydroxy-4-(3-(4-(methoxy)phenyl)-2-methyl-4-(methylsulfonyl)benzoyl)pyrazole 50% inhibition below 20 nM Rattus norvegicus
additional information [1-tert-butyl-3-(2,4-dichlorophenyl)-5-hydroxy-1H-pyrazol-4-yl][2-chloro-4-(methylsulfonyl)phenyl]methanone, no significant inhibition up to 0.02 mM Rattus norvegicus
[1-tert-butyl-3-(2,4-dichlorophenyl)-5-hydroxy-1H-pyrazol-4-yl][2-chloro-4-(methylsulfonyl)phenyl]methanone 50% inhibition at 12 nM Arabidopsis thaliana

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ in octahedral complex with His205, His287, Glu373 and three water molecules Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana P93836
-
-
Rattus norvegicus P32755 expression in Escherichia coli
-

Subunits

Subunits Comment Organism
homodimer crystallization data Arabidopsis thaliana