Literature summary for 1.13.11.27 extracted from

Forbes, B.J.R.; Hamilton, G.A.
Mechanism and mechanism-based inactivation of 4-hydroxyphenylpyruvate dioxygenase (1994), Bioorg. Chem., 22, 343-361.

No PubMed abstract available

Search for more literature for 1.13.11.27

Inhibitors

Inhibitors	Comment	Organism	Structure
2-thienylpyruvate	mechanism-based inhibitor	Sus scrofa
3-thienylpyruvate	mechanism-based inhibitor	Sus scrofa
4-hydroxytetrafluorophenylpyruvate	mechanism-based inhibitor	Sus scrofa
pentafluorophenylpyruvate	competitive	Sus scrofa
thiophenol oxalate	-	Sus scrofa
thiophenyl oxalate	competitive	Sus scrofa

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.041	-	4-hydroxyphenylpyruvate	-	Sus scrofa
0.05	-	4-hydroxytetrafluorophenylpyruvate	-	Sus scrofa
0.066	-	phenylpyruvate	-	Sus scrofa
0.25	-	3-thienylpyruvate	-	Sus scrofa
0.5	-	2-thienylpyruvate	-	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-thienylpyruvate + O2	-	Sus scrofa	? + CO2	-	?
3-thienylpyruvate + O2	-	Sus scrofa	3-carboxymethyl-3-thiolene-2-one + CO2	-	?
4-hydroxyphenylpyruvate + O2	-	Sus scrofa	homogentisate + CO2	-	?
4-hydroxytetrafluorophenylpyruvate + O2	-	Sus scrofa	? + CO2	-	?
phenylpyruvate + O2	-	Sus scrofa	2-hydroxyphenylacetate + CO2	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.014	-	pentafluorophenylpyruvate	-	Sus scrofa
0.15	-	thiophenol oxalate	-	Sus scrofa

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Release 2023.1 (January 2023)