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Literature summary for 1.13.11.27 extracted from

  • Pascal, R.A.; Oliver, M.A.; Chen, Y.C.J.
    Alternate substrates and inhibitors of bacterial 4-hydroxyphenylpyruvate dioxygenase (1985), Biochemistry, 24, 3158-3165.
    View publication on PubMed
Search for more literature for 1.13.11.27

Inhibitors

Inhibitors Comment Organism Structure
(2,6-difluoro-4-hydroxyphenyl)pyruvate competitive, most potent Pseudomonas sp.

Organism

Organism UniProt Comment Textmining
Pseudomonas sp.
-
-
-
Pseudomonas sp. P.J. 874
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2-fluoro-4-hydroxyphenyl)pyruvate + O2
-
 Pseudomonas sp. (3-fluoro-2,5-dihydroxyphenyl)pyruvate + CO2
-
 ?
(2-fluoro-4-hydroxyphenyl)pyruvate + O2
-
 Pseudomonas sp. P.J. 874 (3-fluoro-2,5-dihydroxyphenyl)pyruvate + CO2
-
 ?
4-hydroxyphenylpyruvate + O2
-
 Pseudomonas sp. homogentisate + CO2
-
 ?
4-hydroxyphenylpyruvate + O2
-
 Pseudomonas sp. P.J. 874 homogentisate + CO2
-
 ?
[(4-hydroxyphenyl)thio]pyruvate + O2 substrate undergoes oxidative decarboxylation and sulfoxidation to give [(4-hydroxyphenyl)sulfinyl]acetate, ring oxidation is not observed Pseudomonas sp. [(4-hydroxyphenyl)sulfinyl]acetate + CO2
-
 ?
[(4-hydroxyphenyl)thio]pyruvate + O2 substrate undergoes oxidative decarboxylation and sulfoxidation to give [(4-hydroxyphenyl)sulfinyl]acetate, ring oxidation is not observed Pseudomonas sp. P.J. 874 [(4-hydroxyphenyl)sulfinyl]acetate + CO2
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0013
-
 (2,6-difluoro-4-hydroxyphenyl)pyruvate
-
 Pseudomonas sp.