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Literature summary for 1.13.11.24 extracted from

  • Sun, Y.J.; Huang, Q.Q.; Tano, T.; Itoh, S.
    Flavonolate complexes of M(II) (M = Mn, Fe, Co, Ni, Cu, and Zn). Structural and functional models for the ES (enzyme-substrate) complex of quercetin 2,3-dioxygenase (2013), Inorg. Chem., 52, 10936-10948.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics of enzyme-substrate complexes of the active site of MII-containing quercetin 2,3-dioxygenase, overview Aspergillus japonicus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ required, mononuclear copper(II) active site, binding structure, X-ray diffraction and NMR analysis, overview. Direct coordinative interaction between copper(II) ion and the carboxylate group of Glu73. Complexes modeling, overview Aspergillus japonicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
quercetin + O2 Aspergillus japonicus
-
2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H+
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus japonicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Aspergillus japonicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information quercetin 2,3-dioxygenase activates molecular oxygen to catalyze the oxygenative ring-opening reaction of the O-heterocycle of quercetin to the corresponding depside (phenolic carboxylic acid esters) and carbon monoxide Aspergillus japonicus ?
-
?
quercetin + O2
-
Aspergillus japonicus 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H+
-
?

Subunits

Subunits Comment Organism
homodimer bicupin enzyme Aspergillus japonicus

Synonyms

Synonyms Comment Organism
2,3-QD
-
Aspergillus japonicus

General Information

General Information Comment Organism
additional information synthesis of a series of flavonolate complexes as structural and functional models for the enzyme-substrate complexes of the active site of MII-containing quercetin 2,3-dioxygenase, structure analysis, overview Aspergillus japonicus