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Literature summary for 1.13.11.20 extracted from

  • Puerta, M.; Perata, P.; Hopkinson, R.; Flashman, E.; Licausi, F.; Ratcliffe, P.
    Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants (2019), Science, 364, 65-69 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.20

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0471
-
 O2 cosubstrate N-terminal Cys of RGS5, pH not specified in the publication, 37°C Homo sapiens
0.0551
-
 O2 cosubstrate N-terminal Cys of RGS4, pH not specified in the publication, 37°C Homo sapiens
0.0715
-
 N-terminal Cys of RGS5 pH not specified in the publication, 37°C Homo sapiens
0.123
-
 N-terminal Cys of RGS4 pH not specified in the publication, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96SZ5 cf. EC 1.13.11.19
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-terminal Cys of RGS4 + O2 i.e. regulator of G-protein signalling Homo sapiens N-terminal Cys-sulfinic acid of RGS4
-
 ?
N-terminal Cys of RGS5 + O2 i.e. regulator of G-protein signalling Homo sapiens N-terminal Cys-sulfinic acid of RGS5
-
 ?

Synonyms

Synonyms Comment Organism
ADO
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
16.9
-
 N-terminal Cys of RGS5 pH not specified in the publication, 37°C Homo sapiens
20.1
-
 N-terminal Cys of RGS4 pH not specified in the publication, 37°C Homo sapiens
41.2
-
 O2 cosubstrate N-terminal Cys of RGS5, pH not specified in the publication, 37°C Homo sapiens
56.6
-
 O2 cosubstrate N-terminal Cys of RGS4, pH not specified in the publication, 37°C Homo sapiens

General Information

General Information Comment Organism
physiological function ADO catalyzes conversion of N-terminal cysteine to cysteine sulfinic acid and is related to the plant cysteine oxidases that mediate responses to hypoxia by an identical post-translational modification. In human cells ADO regulates the RGS4/5 (regulator of G-protein signalling) N-degron substrates, modulates G-protein coupled Ca2+ signals and MAPK activity, and acts on N-terminal cysteine proteins including the angiogenic cytokine IL-32. Inactivation of ADO leads to constitutive upregulation of endogenous and transfected RGS4 and RGS5 proteins irrespective of oxygen levels Homo sapiens