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Literature summary for 1.13.11.20 extracted from
- Cysteine dioxygenase is essential for mouse sperm osmoadaptation and male fertility (2018), FEBS J., 285, 1827-1839 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P60334 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epididymis | androgen-dependent CDO expression is highest in the caput epididymidis | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CDO1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | CDO-/- mouse sperm demonstrates a severe lack of in vitro fertilization ability. Acrosome exocytosis and tyrosine phosphorylation profiles in response to stimuli are normal. CDO-/- sperm has a slight increase in head abnormalities. Taurine and hypotaurine concentrations in CDO-/- sperm decrease in the epididymal intraluminal fluid and sperm cytosol. No evidence of antioxidant protection against lipid peroxidation is found. CDO-/- sperm exhibits severe defects in volume regulation, swelling in response to the relatively hypo-osmotic conditions found in the female reproductive tract | Mus musculus |
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Release 2023.1 (January 2023)
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