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Literature summary for 1.13.11.20 extracted from

  • Blaesi, E.J.; Gardner, J.D.; Fox, B.G.; Brunold, T.C.
    Spectroscopic and computational characterization of the NO adduct of substrate-bound Fe(II) cysteine dioxygenase: insights into the mechanism of O2 activation (2013), Biochemistry, 52, 6040-6051.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene cdo, expression as N-terminal maltose-binding protein fusion protein in Escherichia coli strain BL21(DE3)RIPL Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ a a mononuclear nonheme iron(II)-dependent enzyme. It possesses both an unusual 3-His facial ligation sphere to the iron center and a rare Cys-Tyr crosslink near the active site Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-cysteine + O2 Mus musculus
-
3-sulfinoalanine
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
gene cdo
-

Purification (Commentary)

Purification (Comment) Organism
recombinant N-terminal maltose-binding protein fusion enzyme from Escherichia coli strain BL21(DE3)RIPL by anion exchange and amylose affinity chromatography Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cysteine + O2
-
Mus musculus 3-sulfinoalanine
-
?
additional information no activity with selenocysteine Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
CDO
-
Mus musculus
Fe(II) cysteine dioxygenase
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus

General Information

General Information Comment Organism
additional information NO as a substrate analogue for O2 is used to prepare a species that mimics the geometric and electronic structures of an early reaction intermediate, analysis by magnetic circular dichroism, electron paramagnetic resonance, and electronic absorption spectroscopies as well as computational methods including density functional theory and semiempirical calculations, quantum mechanics/molecular mechanics calculations, overview. The NO adducts of Cys- and selenocysteine (Sec)-bound Fe(II)CDO exhibit virtually identical electronic properties Mus musculus
physiological function cysteine dioxygenase is a mononuclear nonheme iron(II)-dependent enzyme critical for maintaining appropriate cysteine and taurine levels in eukaryotic systems Mus musculus