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Literature summary for 1.13.11.20 extracted from

  • Cresenzi, C.L.; Lee, J.I.; Stipanuk, M.H.
    Cysteine is the metabolic signal responsible for dietary regulation of hepatic cysteine dioxygenase and glutamate cysteine ligase in intact rats (2003), J. Nutr., 133, 2697-2702.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information cysteine mediates the up-regulation of enzyme in cultured hepatocytes Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ metalloenzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-cysteine + O2 Rattus norvegicus key enzyme of taurine biosynthesis, provides substrate for transamination, regulation of intracellular cysteine level 3-sulfino-L-alanine
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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male Sprague-Dawley rats, low enzyme level in rats fed a low protein diet, high enzyme level when low protein diet is supplemented with cysteine, homocystine, or methionine
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary cell culture Rattus norvegicus
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liver
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cysteine + O2
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Rattus norvegicus 3-sulfino-L-alanine
-
?
L-cysteine + O2 key enzyme of taurine biosynthesis, provides substrate for transamination, regulation of intracellular cysteine level Rattus norvegicus 3-sulfino-L-alanine
-
?