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Literature summary for 1.13.11.15 extracted from

  • Hayden, J.A.; Farquhar, E.R.; Que, L.; Lipscomb, J.D.; Hendrich, M.P.
    NO binding to Mn-substituted homoprotocatechuate 2,3-dioxygenase: relationship to O2 reactivity (2013), J. Biol. Inorg. Chem., 18, 717-728.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.15

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ Fe2+-containing homoprotocatechuate 2,3-dioxygenase, FeHPCD, activates O2 to catalyze the aromatic ring opening of homoprotocatechuate Brevibacterium fuscum
Mn2+ can substitute for Fe2+ in catalysis Brevibacterium fuscum
additional information the enzyme requires Fe2+ for catalysis, but Mn2+ can be substituted (MnHPCD) with essentially no change in the steady-state kinetic parameters, spectral analysis, overview Brevibacterium fuscum
NO NO binding to a non-heme enzyme containing manganese allows examination of the factors governing the formation and detection of the MIII-O2.- species in all forms of th enzyme. NO, and presumably O2, binding is sensitive to both the nature of the catecholic substrate present and the nature of the active-site amino acid residue at position 200, spectral analysis, overview Brevibacterium fuscum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,4-dihydroxyphenylacetate + O2 Brevibacterium fuscum
-
 2-hydroxy-5-carboxymethylmuconate semialdehyde
-
 ?

Organism

Organism UniProt Comment Textmining
Brevibacterium fuscum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-dihydroxyphenylacetate + O2
-
 Brevibacterium fuscum 2-hydroxy-5-carboxymethylmuconate semialdehyde
-
 ?
3,4-dihydroxyphenylacetate + O2 Fe2+-containing homoprotocatechuate 2,3-dioxygenase, FeHPCD, activates O2 to catalyze the aromatic ring opening of homoprotocatechuate. O2 activation steps for extradiol dioxygenases, mechanism, overview Brevibacterium fuscum 2-hydroxy-5-carboxymethylmuconate semialdehyde
-
 ?

Synonyms

Synonyms Comment Organism
FeHPCD
-
 Brevibacterium fuscum
homoprotocatechuate 2,3-dioxygenase
-
 Brevibacterium fuscum
MnHPCD
-
 Brevibacterium fuscum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 assay at Brevibacterium fuscum

General Information

General Information Comment Organism
additional information the enzyme requires Fe2+ for catalysis, but Mn2+ can be substituted (MnHPCD) with essentially no change in the steady-state kinetic parameters, spectral analysis, overview Brevibacterium fuscum