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Literature summary for 1.12.1.3 extracted from

  • van Haaster, D.J.; Silva, P.J.; Hagedoorn, P.L.; Jongejan, J.A.; Hagen, W.R.
    Reinvestigation of the steady-state kinetics and physiological function of the soluble NiFe-hydrogenase I of Pyrococcus furiosus (2008), J. Bacteriol., 190, 1584-1587.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
CO 0.02 mM, 50% inhibition Pyrococcus furiosus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.018
-
H2 cosubstrate: benzyl viologen Pyrococcus furiosus
0.02
-
H2 cosubstrate: methyl viologen Pyrococcus furiosus
0.037
-
NADP+
-
Pyrococcus furiosus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Pyrococcus furiosus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2 + NADP+ Pyrococcus furiosus the enzyme likely functions in the regeneration of NADPH and thus reuses the hydrogen produced by the membrane-bound hydrogenase in proton respiration H+ + NADPH
-
r

Organism

Organism UniProt Comment Textmining
Pyrococcus furiosus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2 + NADP+ the enzyme likely functions in the regeneration of NADPH and thus reuses the hydrogen produced by the membrane-bound hydrogenase in proton respiration Pyrococcus furiosus H+ + NADPH
-
r
H2 + NADP+ the hydrogen consumption activity is 1 order of magnitude higher than the hydrogen production activity Pyrococcus furiosus H+ + NADPH
-
r
H2 + oxidized benzyl viologen
-
Pyrococcus furiosus H+ + reduced benzyl viologen
-
?
H2 + oxidized methyl viologen
-
Pyrococcus furiosus H+ + reduced methyl viologen
-
?