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Literature summary for 1.12.1.2 extracted from

  • Petrov, R.R.; Utkin, I.B.; Popov, V.O.
    Effect of redox potential on the activation of the NAD-dependent hydrogenase from Alcaligenes eutrophus Z1 (1989), Arch. Biochem. Biophys., 268, 287-297.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information at a redox potential of approx. -100 mV the inactive form of the enzyme is transformed into an active one Cupriavidus necator

General Stability

General Stability Organism
oxidized inactive form of the enzyme is the most stable against thermodenaturation, proteolysis, and inactivation in urea Cupriavidus necator

Organism

Organism UniProt Comment Textmining
Cupriavidus necator
-
-
-
Cupriavidus necator
-
formerly Alcaligenes eutrophus
-
Cupriavidus necator Z1
-
-
-

Oxidation Stability

Oxidation Stability Organism
redox-dependent inactivation and activation, proposed inactivation mechanism Cupriavidus necator

Reaction

Reaction Comment Organism Reaction ID
H2 + NAD+ = H+ + NADH catalytic activity may be regulated by the reduction of a regulatory center followed by a series of structural changes Cupriavidus necator

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2 + NAD+
-
Cupriavidus necator H+ + NADH
-
?
H2 + NAD+
-
Cupriavidus necator Z1 H+ + NADH
-
?