Application | Comment | Organism |
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analysis | detection of myeloperoxidase activity in vivo by use of a paramagneitc substrate. The sensing probe is obtained by replacing the reducing substrate serotonin with 5-hydroxytryptophan. The resulting probe bis-hydroxytryptophan-gadolinium diethylenetriamine pentaacetic acid in vitro improves solubility in water, acts as a substrate, induces cross linking of proteins in the presence of myeloperoxidase,produces oxidation products which bind to plasma proteins and does not follow first order reaction kinetics. Bis-hydroxytryptophan-gadolinium diethylenetriamine pentaacetic acid is retained for up to five days in myeloperoxidase-containing sites and cleared faster than serotonin diethylenetriamine pentaacetic acid from enzyme-negative sites | Mus musculus |
Organism | UniProt | Comment | Textmining |
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Mus musculus | - |
- |
- |