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Literature summary for 1.11.2.2 extracted from
- pH-dependent regulation of myeloperoxidase activity (2006), Biochemistry, 71, 667-677.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| phagosome | - |
Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Cl- + H2O2 + H+ | at acidic pH, chlorinating activity of MPO dominates | Homo sapiens | HClO + H2O | - |
? |  |
| guaiacol + H2O2 | at neutral pH MPO has higher affinity to peroxidase substrate guaiacol | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MPO | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.7 | 6 | optimum pH for peroxidase activity of MPO | Homo sapiens |
| 7.4 | - |
optimum pH for chlorinating activity of MPO, at pH 7.4 chloride ions do not compete with guaiacol up to the concentration of 150 mM | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | balance between peroxidase and chlorinating activities of myeloperoxidase is very important for the enhancement of antimicrobial action and prevention of damage caused by hypochlorite | Homo sapiens |
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