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Literature summary for 1.11.2.2 extracted from

  • Blair-Johnson, M.; Fiedler, T.; Fenna, R.
    Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolution (2001), Biochemistry, 40, 13990-13997.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, native MPO is crystallized with 16% (w/v) polyethylene glycol (PEG) 8000, 50 mM ammonium sulfate, 50 mM sodium acetate, 2 mM calcium acetate, and 50 mM sodium thiocyanate at 22°C and pH 5.5 for 24 h Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cyanide
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P05164
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cl- + H2O2 + H+
-
Homo sapiens HClO + H2O
-
?
thiocyanate + H2O2 + H+
-
Homo sapiens hypothiocyanate + H2O
-
?

Subunits

Subunits Comment Organism
homodimer x-ray crystallography Homo sapiens

Synonyms

Synonyms Comment Organism
donor, hydrogen peroxide oxidoreductase
-
Homo sapiens
EC 1.11.1.7
-
Homo sapiens
MPO
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
Homo sapiens