Activating Compound | Comment | Organism | Structure |
---|---|---|---|
serotonin | at low micromolar concentrations (below 0.02 mM), serotonin enhances hypochlorite production by both purified myeloperoxidase and neutrophils | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
serotonin | at higher concentrations than 0.02 mM, serotonin almost completely blocks the formation of hypochlorite | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ascorbate + H2O2 | Homo sapiens | - |
? | - |
? | |
Br- + H2O2 | Homo sapiens | - |
? | - |
? | |
Cl- + H2O2 | Homo sapiens | main reducing substrate for myeloperoxidase | HClO + H2O | - |
? | |
nitric oxide + H2O2 | Homo sapiens | - |
? | - |
? | |
nitrite + H2O2 | Homo sapiens | - |
? | - |
? | |
thiocyanate + H2O2 | Homo sapiens | - |
hypothiocyanite + H2O | - |
? | |
tyrosine + H2O2 | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05164 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ascorbate + H2O2 | - |
Homo sapiens | ? | - |
? | |
Br- + H2O2 | - |
Homo sapiens | ? | - |
? | |
Cl- + H2O2 | main reducing substrate for myeloperoxidase | Homo sapiens | HClO + H2O | - |
? | |
nitric oxide + H2O2 | - |
Homo sapiens | ? | - |
? | |
nitrite + H2O2 | - |
Homo sapiens | ? | - |
? | |
serotonin + H2O2 | favoured substrate of myeloperoxidase, only ascorbate blocks oxidation of serotonin | Homo sapiens | serotonin dimer + H2O | - |
? | |
serotonin + superoxide | - |
Homo sapiens | tryptamine-4,5-dione + H2O | - |
? | |
thiocyanate + H2O2 | - |
Homo sapiens | hypothiocyanite + H2O | - |
? | |
tyrosine + H2O2 | - |
Homo sapiens | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | oxidation of serotonin by myeloperoxidase may profoundly influence inflammatory processes | Homo sapiens |