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Literature summary for 1.11.2.2 extracted from
- Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid (2005), Biochem. Biophys. Res. Commun., 332, 837-844.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| betanin | low micromolar betanin concentrations enhance the chlorination activity of MPO at pH 7.0, increasing the betanin concentration up to 0.006 mM dramatically increases the chlorination rate of monochlorodimedon | Homo sapiens |  |
| indicaxanthin | at neutral pH and depending on their concentration, indicaxanthin can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO | Homo sapiens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| betanin | higher micromolar betanin concentrations inhibit the MPO-mediated chlorination reactions by scavenging of hypochlorous acid | Homo sapiens | |
| indicaxanthin | at neutral pH and depending on their concentration, indicaxanthin can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO, whereas at pH 5.0 only inhibitory effects are observed even at micromolar concentrations | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Cl- + H2O2 | Homo sapiens | - |
HClO + H2O | - |
? | |
| monochlorodimedon + Cl- | Homo sapiens | - |
dichlorodimedon | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Cl- + H2O2 | - |
Homo sapiens | HClO + H2O | - |
? | |
| monochlorodimedon + Cl- | - |
Homo sapiens | dichlorodimedon | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MPO | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
- |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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