Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2,2'-dihydroxy-4-methoxy benzophenone | increases the enzyme activity by about 1.5fold | Homo sapiens | |
2,4-dihydroxy benzophenone | increases the enzyme activity by about 1.5fold | Homo sapiens | |
dibenzo(a,h)anthracene | 2fold activation between 0.01 and 0.1 mM | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in FTC-238 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,2',4,4'-tetrahydroxybenzophenone | inhibits enzyme activity by more than 60% from 0.00001 to 0.1 mM | Homo sapiens | |
3-methylcholanthrene | - |
Homo sapiens | |
benzhydrol | reduces the enzyme activity by about 30% from 0.01 to 0.1 mM | Homo sapiens | |
benzo(e)pyrene | - |
Homo sapiens | |
benzo(k)fluoranthene | - |
Homo sapiens | |
benzophenone | - |
Homo sapiens | |
genistein | inhibits enzyme activity by about 40% at 0.001 and 0.01 mM | Homo sapiens | |
heptachlor | weakly inhibits the enzyme activity by about 50% at 0.01 mM | Homo sapiens | |
Methimazole | enzyme activity is reduced by more than 70% by 0.1 and 1 mM | Homo sapiens | |
additional information | 2,3,4-trihydroxybenzophenone, 2,4,4'-trihydroxybenzophenone, 4-hydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, chrysene, naphthalene, benzo(a)anthracene, phenanthrene, hexachlorobenzene, mirex, chlordane, and methylmercury have no effect on enzyme activity | Homo sapiens | |
perfluorooctane sulfonate | - |
Homo sapiens | |
Perfluorooctanoic acid | slight inhibition at 0.01 mM | Homo sapiens | |
pyrene | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thyroid epithelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guaiacol + H2O2 + H+ | - |
Homo sapiens | 3,3'-dimethoxy-4,4'-biphenoquinone + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thyroid peroxidase | - |
Homo sapiens |
thyroperoxidase | - |
Homo sapiens |
TPO | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme catalyzes the transfer of iodine to thyroglobulin during thyroid hormone synthesis | Homo sapiens |